Choroid Disease, Myopia, Progressive
Conditions
Keywords
OCTA, Myopia, Choroid
Brief summary
Myopia is a global healthy concern, especially the high myopia and pathological myopia among Asian populations. However, its mechanism still remains largely unclear. Recent findings suggested choroidal changes might be related to the development of myopia. This study is to useOCT angiography (OCT-A) to investigate parapapillary choroidal microvasculature change in myopic eyes, and try to find the cause-and-effect relationship between choroidal change and the development of myopia.
Interventions
DEVICEOptic coherence tomography angiography (OCTA)
Using non-invasive, repeatable, mature device OCTA to obtain choroidal angio-map
Sponsors
The First Affiliated Hospital with Nanjing Medical University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
1. Spherical equivalent measurement can be included in above 4 groups 2. Willing to be followed up in the future 10 years
Exclusion criteria
1. Deny to sign the patient consent, or deny to be followed 2. Evidence of cardiac, or diabetic, or CNS disease. 3. Clinically diagnosed with retinal or choroidal disease 4. Glucoma 5. Cataract or corneal disease that influence the quality of fundus OCTA image
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Parapapillary choroidal microvasculature void (MvV) area | changes of MvV area from at 10 years | area of parapapillary choroidal microvasculature void on OCTA images |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MvV number | baseline | number of choroidal MvV with certain size |
| Correlation coefficient between choroidal MvV and refractive power | baseline | Correlation coefficient between choroidal MvV and refractive power |
| Correlation coefficient between choroidal MvV and PPA area | baseline | Correlation coefficient between choroidal MvV and parapapillary atrophy beta area |
| Correlation coefficient between choroidal MvV and RNFL thickness | baseline | Correlation coefficient between choroidal MvV and RNFL thickness |
| Correlation coefficient between choroidal MvV and Axial length | baseline | Correlation coefficient between choroidal MvV and Axial length |
| Correlation coefficient between choroidal MvV and retinal parapapillary perfusion | baseline | Correlation coefficient between choroidal MvV and retinal parapapillary perfusion on OCTA images. |
| Correlation coefficient between choroidal MvV and Macular perfusion | baseline | Correlation coefficient between choroidal MvV and Macular perfusion on OCTA images, Retinal parapapillary perfusion with OCTA. |
| Correlation coefficient between choroidal MvV and choroid thickness | baseline | Correlation coefficient between choroidal MvV and choroid thickness |
Countries
China
Contacts
Primary ContactZizong Hu, PhD, MD
Backup ContactQinghuai Liu, PhD, MD
Outcome results
None listed