ERCP
Conditions
Keywords
Pancreatic duct negative-pressure suction
Brief summary
The investigators hypothesized that naso-pancreatic duct suction could benefit for patients with severe biliary pancreatitis undergoing ERCP. So, the investigators designed this experiment to verify it.
Detailed description
This project intends to conduct treatment based on different interventions for enrolled subjects according to international and domestic standardized treatment procedures, including 1.ERCP stone extraction, duodenal papillary pressure measurement, bile duct pressure measurement, and nasal bile duct placement; 2.ERCP+ duodenal papillary pressure measurement, biliopancreatic duct pressure measurement + nasopancreatic duct + determine whether nasopancreatic duct negative pressure attraction.Compare the advantages of two different treatment methods.This paper attempts to explore new treatment methods that are more conducive to the rehabilitation of patients and provides an important preliminary research basis for the future clinical application of standardized treatment. Patients from the people's hospital of Wuhan university were recruited and selected into groups. The incidence, recurrence rate, operation time and hospital stay of the two independent samples will be compared.
Interventions
PROCEDUREexperiment
Treatment was randomly selected according to preoperative grouping. After ERCP, naso-pancreatic drainage was chosen as treatment。
PROCEDUREcontrol
Treatment was randomly selected according to preoperative grouping. After ERCP, nasobiliary drainage was chosen as treatment。
Sponsors
Renmin Hospital of Wuhan University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
16 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Ages 16 to 75. Apach-ii score of patients diagnosed with pancreatitis was greater than 8 points. Liver function can be damaged. Elevated indicators of pancreatitis (hematuria amylase, lipase). Identify patients with biliary tract infection or obstruction.
Exclusion criteria
Older than 75 or younger than 16. The duration of admission was more than 72 hours. Gastrointestinal obstruction endoscopy cannot be operated. Patients with duodenoscopy contraindications.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rehabilitation | 2 months | time from ERCP to ischarge |
| complication rate | 1 months | Pancreatitis aggravation， hemorrhage，fistula |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| LOS(length of stay) | postoperative period（1 month ） | time from operation to discharge |
| death rate | postoperative period（1 month ） | Mortality from the disease |
Countries
China
Contacts
Primary ContactQiong Gong, Doctor
Backup ContactZ'hong'chao Zhu, Doctor
Outcome results
None listed