Obstructive Sleep Apnea
Conditions
Brief summary
The role of control of peri-pharyngeal muscle tone in the pathogenesis of obstructive sleep apnea (OSA) is obvious: pharyngeal obstruction occurs only during sleep; and pharyngeal collapse occurs in almost all healthy subjects during anesthesia. Better understanding of these control mechanisms may help identifying the central components of the pathogenesis of OSA.
Detailed description
Study plan: Subjects will be studied first during wakefulness, while breathing against external resistors, to evaluate how are the peri-pharyngeal muscles recruited and activated to prevent pharyngeal collapse in the presence of negative intra-pharyngeal pressures. Thereafter, the same parameters will be evaluated during sleep, to assess muscle recruitment during intra-pharyngeal obstruction. The investigaors will record the electromyogram (EMG) of several dilator muscles, as well as the pressures above and below the area of pharyngeal collapse, and airflow.
Interventions
OTHERpatients with OSA
Sleep study
Sponsors
Bnai Zion Medical Center
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1\. subjects that underwent regular sleep studies and found to have either moderate/severe OSA, or no OSA. \-
Exclusion criteria
1. hemophilia 2. use of anti-coagulants -
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| EMG activity of peri-pharyngeal muscles during wakefulness and sleep | 4 hours | EMG of peripharyngeal muscles will be measured during wakefulness (on external resistors) and sleep (during flow limitation), patients with OSA. EMG data will be presented as %max (0-100%). |
Outcome results
None listed