Hypothermia Due to Cold Environment
Conditions
Keywords
Body Temperature, Skin Temperature, Cooling
Brief summary
This study characterizes the changes in corticospinal excitability that accompany basic cold stress via skin cooling that result in reduced skin or core temperature and shivering.
Detailed description
Cold stress is known to impair both fine and gross motor movement. Reductions in performance may have life threatening consequences in survival situations where maintenance of muscle control is necessary. Much of the effects cooling has on muscle performance is directly due to its effects on muscle tissue itself, whereas less is known about the effects on the central nervous system. Therefore, the purpose of the study was to characterize corticospinal excitability that accompanies basic cold stress via progressive skin cooling, resulting in reductions in skin (Tsk) or core (Tco) temperature and shivering.
Interventions
OTHERCold Stress
60-90 mins of cooling via a liquid perfused suit circulating \ 4-10°C liquid.
Sponsors
University of Manitoba
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Repeat Measures
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy adult * Right Handed * Pass Magnetic Stimulation Safety Checklist * Pass Medical Screening Questionnaire
Exclusion criteria
* Left Handed * Any adverse responses to cold exposure (Raynaud's Syndrome) * Cardiorespiratory Disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Corticospinal Excitability | at 0, 20, 40, 60 and 90 minutes | Motor Evoked Potentials (MEP) as a percentage of the maximal compound muscle action potential (Mmax) measured via MEG at the Biceps Brachii will serve as the indices of Corticospinal excitbaility |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Skin Temperature | at 0, 20, 40, 60 and 90 minutes | Mean skin temperature of 7 sites |
| Change in Core Temperature | at 0, 20, 40, 60 and 90 minutes | Esophageal temperature is the most accurate method representing the temperature of the heart. |
| Change in Spinal Excitability | at 0, 20, 40, 60 and 90 minutes | Cervicomedullary Motor Evoked Potentials (CMEP) as a percentage of the maximal compound muscle action potential (Mmax) measured via MEG at the Biceps Brachii will serve as the indices of spinal excitability |
| Change in Metabolic Heat Production | at 0, 20, 40, 60 and 90 minutes | Metabolic heat production serves as an objective way to quantify shivering thermogenesis. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change in Peripheral nerve excitability | at 0, 20, 40, 60 and 90 minutes | Excitability of the peripheral nerve measured via EMG at the biceps brachia ( the maximal compound motor action potential (Mmax). |
| Change in Maximal Voluntary Contraction of Elbow Flexors | at 0, 20, 40, 60 and 90 minutes | Maximal Isometric Force of elbow flexors measured in kg of force |
Countries
Canada
Outcome results
None listed