Risk of Recurrence of Cervical Artery Dissection During Pregnancy and Puerperium

A Prospective Study to Evaluate the Risk of Recurrence of Cervical Artery Dissection During Subsequent Pregnancies

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04253535

Enrollment

Registered

2020-02-05

Start date

2020-02-14

Completion date

2020-06-15

Last updated

2020-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical Artery Dissection

Keywords

Pregnancy, Puerperium Recurrence, Cervical artery dissection

Brief summary

Cervical artery dissection (CAD) accounts for about 2% of all strokes, and is a major cause of stroke in young people (about 15%). Many cases of CAD during pregnancy and puerperium have been described, suggesting that pregnancy and puerperium may be potential risk factors for CAD. The purpose of this study is to determine whether pregnancy and puerperium are also recurrence risk factors for CAD.

Detailed description

In this study, all women of childbearing age who had had a CAD between 2005 and 2017 are selected. Women are identified using the ICD10 diagnostic coding system. In addition, a text search with key words (cervical or carotid or vertebral dissection) has been created in a data warehouse of the University Hospital of Nantes. To determine the recurrence of CAD during pregnancy and puerperium, the participating women will be asked to answer to a questionnaire, by phone or mail. The questionnaire will be conducted by the same investigator, an experienced neurologist. Information about recurrence of CAD, number of pregnancies before and after the event will be recorded, as well as, the site of obstetrical monitoring, way of delivery, and management of antithrombotics, in case of further pregnancy. In case of no further pregnancy after the dissection, the reason will be explored.

Interventions

OTHERquestionnaries

Study on questionnaries

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Extracranial carotid or vertebral dissection * Symptomatic dissection (with symptom onset within the last four weeks) * Spontaneous dissection * Imaging evidence of dissection on MRI/MRA, CTA or ultrasound.

Exclusion criteria

* Minors or adults under guardianship * Intracranial artery dissection * Traumatic or iatrogenic dissection * Patient refusal to participate

Design outcomes

Primary

Measure	Time frame	Description
Recurrence of CAD during pregnancy, childbirth or puerperium	Day 0	This primary study endpoint will be evaluated by a questionnaire asked directly to participating women.

Secondary

Measure	Time frame	Description
To determine the absolute risk of recurrence of CAD in this population.	Day 0	This secondary endpoint will be evaluated by a questionnaire asked directly to participating women.
To assess obstetrical monitoring, way of delivery, and management of antithrombotics during further pregnancy.	Day 0	This secondary endpoint will be evaluated by a questionnaire asked directly to participating women.
To study the reasons of absence of pregnancy after a history of CAD	Day 0	This secondary endpoint will be evaluated by a questionnaire asked directly to participating women.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026