ART, Embryo Transfer, Female Infertility, Progesterone
Conditions
Brief summary
The association between serum progesterone (P) levels, measured on the day of ovulation trigger, and the outcome of in vitro fertilization cycles, has been one of the major controversies in the field of ovarian stimulation endocrinology. This is a single-center retrospective cohort study. Study duration period is from January 2012 to December 2016. All fresh embryo transfer (ET) both at cleavage stage and blastocyst stage, performed in Humanitas Fertility Center during the study period, were included.
Interventions
OTHERembryo transfer
Step of the assisted reproduction in which embryos are placed into the uterus in order to obtain a pregnancy
Sponsors
Istituto Clinico Humanitas
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* All fresh embryo transfers both at cleavage stage (Day 2 and Day3) and blastocyst stage (Day 5) * Thawed embryo transfer deriving from supernumerary embryos cycles, by P increase, by OHSS, by other reasons (i.e inadequate endometrium, medical complications, etc)
Exclusion criteria
* thawed embryo transfers deriving from PGTA.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Impact of PE on CPR and LBR | January 2012-December 2016 | To evaluate the impact of premature high serum P levels on the outcome of fresh embryo transfer cycles in terms of Clinical Pregnancy Rates (CPR) and Live Birth Rates (LBR). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blastocyst embryo transfers' outcomes in PE | January 2012-December 2016 | Furthermore, the present study retrospectively investigates whether the transfer of blastocysts on day 5 post-fertilization (D5-ET) may improve the CPR and the LBR in patients with P rise. |
Countries
Italy
Outcome results
None listed