Pregnancy Related
Conditions
Brief summary
The present study is to compare the onset and duration of rocuronium in late second trimester women and non-pregnant women undergoing general anesthesia.
Detailed description
Pregnancy induces physiological changes. Plasma volume, cardiac output, hepatic blood flow and protein binding are changed from the first trimester of pregnancy. These physiological changes give effect to the onset and duration of neuromuscular blocking drugs. Rocuronium is a commonly used neuromuscular blocking drug categorized as FDA category B. Rocuronium is widely used for pregnant women. Previous studies have evaluated the onset and duration of rocuronium in postpartum women. Lately, the investigators have evaluated the onset and duration of rocuronium in early second trimester pregnant women and the duration was significantly longer in early second trimester women compared to non-pregnant women. Since there is little research on the onset and duration of rocuronium in the late second trimester pregnant women, the investigators planned the present research.
Interventions
None listed
Sponsors
Hallym University Kangnam Sacred Heart Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 45 Years
Inclusion criteria
* women undergoing general anesthesia
Exclusion criteria
* liver disease * renal disease * diabetes mellitus * asthma * allergic to specific drugs * BMI\>30 or \<18
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| duration of rocuronium | time measured to 25% recovery with T1 using Train of Four watch, assessed upto 1 hour | time measured with TOFwatch-SX |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| onset of rocuronium | time measured to 0% depression of T1 using Train of Four watch, assessed upto 5 minutes | time measured with TOFwatch-SX |
Countries
South Korea
Contacts
Primary ContactInJung Jun
Outcome results
None listed