The Impact of Gut Microbiota in Anastomoses Insufficiency After Resection and Direct Anastomosis for Colorectal Cancer.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04252560

Enrollment

Registered

2020-02-05

Start date

2020-01-31

Completion date

2024-01-31

Last updated

2024-05-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer, Peritoneal Carcinomatosis, Anastomosis Insufficiency

Brief summary

The role of gut microbiota in anastomosis insufficiency in patients operated for colorectal cancer and for peritoneal carcinomatosis is going to be investigated. This is a pilot study.

Interventions

PROCEDUREColectomy, CRS+HIPEC

No special interventions are going to be performed. Fecal samples are going to be taken and analysed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Colorectal group * adenocarcinom in colon or rektum * curative operation planed * direct anastomose plan * elective surgery Inclusion Criteria HIPEC group : * All patients with appendix, colon or rectal cancer accepted for CRS+HIPEC

Exclusion criteria

* Ongoing antibiotics treatment * antibiotics treatment in the last 6 months * acute surgery * palliative surgery * Ulcerös colitis or Crohns disease * Prior colectomy * Small intestine stoma before the operation * neoadjuvant treatment * Colon preparation

Design outcomes

Primary

Measure	Time frame	Description
Microbiome	30 days	Change in microbiome in case of insufficiency of the anastomosis

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026