Critically Ill Patients
Conditions
Keywords
Pharmacokinetics, Fluconazole, Variability, Target attainment
Brief summary
This prospective study will research the exposure and its variability to fluconazole after longitudinal administration in critically ill patients
Detailed description
An open label, monocenter pharmacokinetic study will be carried out in critically ill patients, admitted at the University Hospitals Leuven, receiving multiple dose treatment with fluconazole. The exposure to fluconazole in the ICU cohort over multiple days of treatment will be documented. Moreover, variability and the correlating covariates that can influence the fluconazole concentration, will be determined.
Interventions
OTHERSample collection
Plasma and urine sample collection
Sponsors
KU Leuven
Universitaire Ziekenhuizen KU Leuven
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \> 18 years * Treatment with fluconazole * Admitted to an ICU ward
Exclusion criteria
* \< 18 years * DNR 2 or 3
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exposure to fluconazole (trough levels) | On the day of sampling | To document the trough levels (Cmin) of fluconazole in an ICU cohort over multiple days of treatment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Variability in fluconazole trough levels | June 2020 | To determine the intra-and intersubject variability of the fluconazole trough levels |
| Influencing covariates | June 2020 | Determine possible covariates that might explain the fluconazole variability |
Countries
Belgium
Outcome results
None listed