Bipolar Disorder, Light Sensitivity
Conditions
Keywords
Circadian, Light Intensity
Brief summary
The purpose of this mechanistic study is to examine light sensitivity (melatonin suppression) in people with bipolar depression I, and compare it to healthy controls. This is not a treatment study.
Detailed description
The bipolar disorder I and healthy control arms are recruited from the existing Heinz C. Prechter Bipolar Research Program at the University of Michigan.
Interventions
OTHERLight intensity, ~30 lux
\ 30 lux compared to very dim light baseline condition \<1 lux
OTHERBaseline light intensity, <1 lux
Very dim light condition
Sponsors
University of Michigan
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Masking description
There is no masking. The dim light (\<1 lux) condition is first, followed by the room light (\ 30 lux) condition. Participants are aware of this condition order.
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 18-30 kg/m2 * Appropriate sleep schedules according to study staff. Sleep schedule is self-reported and confirmed through a sleep diary * Healthy eyes as ascertained by eye exam at University of Michigan Kellogg Eye Center * Willing and able to maintain stable sleep schedule during study. * Participants will be breathalyzed and undergo urine drugs screens at every lab visit * Acknowledge and understand that participants cannot drive themselves home after certain lab visits. Note that the research team will provide a travel stipend of $10 per visit to offset potential rideshare/taxi costs
Exclusion criteria
* Color blindness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Melatonin levels | Up to approximately 6 weeks | Melatonin will be reported as an average percentage of suppression in the \ 30 lux condition as compared to \<1 lux |
Countries
United States
Outcome results
None listed