Gallstones, Gastric Cancer
Conditions
Keywords
Gallstones, Gastric cancer, Gastrectomy, ESD, Vagus nerve
Brief summary
Through previous clinical observations and literature, we found that the incidence of gallstones in patients after gastric cancer radical resection was significantly higher than that in the normal population (4%). However, its pathogenesis has not been clarified. We compare the risk of gallbladder stones after four different radical gastric cancer surgical methods, in order to provide prevention and treatment strategies for people with gallstones after gastric cancer.
Detailed description
A large number of clinical studies have found that the incidence of gallstones in patients with radical gastric cancer is higher than that in the normal population. However, its pathogenesis has not been clarified, and there is still controversy about the prophylactic removal of gallbladder in patients with gastric cancer. The investigator's previous study found that there was no statistical difference in the incidence of gallstones after laparoscopic distal gastrectomy (LDG), laparoscopic total gastrectomy (LTG) and laparoscopic proximal gastrectomy (LPG). A common feature of the three surgical methods is that the vagus nerve were more or less cut during the operation. Therefore, we plan to further collect gastric cancer patients undergoing endoscopic submucosal dissection (ESD) surgery in order to answer whether the vagus nerve cut during surgery will increase the incidence of gallstones.
Interventions
PROCEDUREResection
Radical resection.
Sponsors
Hepatopancreatobiliary Surgery Institute of Gansu Province
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Gastric cancer patients * Age from over 18 to under 75 years
Exclusion criteria
* Gallbladder disease before surgery * Gallbladder has been remove * History of previous upper abdominal surgery * History of previous gastrectomy, endoscopic mucosal resection or endoscopic submucosal dissection * History of other malignant disease within past five years * History of previous neoadjuvant chemotherapy or radiotherapy * History of unstable angina or myocardial infarction within past six months * History of cerebrovascular accident within past six months * Requirement of simultaneous surgery for other disease * Emergency surgery due to complication (bleeding, obstruction or perforation) caused by gastric cancer * Pregnant women or breastfeeding * Unwillingness or inability to consent for the study * Severe mental disorder * Unstable vital signs Coagulation dysfunction (INR\>1.5) * Low peripheral blood platelet count (\<50×10 \^9 / L) or using anti- coagulation drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of gallstone patients | 3 years | Four different gastric cancer patients were followed up for more than 1 year. The number of patients with gallbladder stones revealed by B-ultrasound |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of malignant metastasis | 3 years | Number of malignant metastases after radical gastrectomy in surgery methods of gastric cancer patients |
| Number of short-term deaths | 3 months | Number of short-term deaths after radical gastrectomy in surgery methods of gastric cancer patients |
| Number of physical regurgitation, nausea, vomiting, diarrhea, constipation | 3 years | The number of physical regurgitation, nausea, vomiting, diarrhea, constipation, and other events that affect quality of life in four surgery methods of gastric cancer patients |
Countries
China
Outcome results
None listed