Blood Transfusion, Hypoxia Neonatal, Premature
Conditions
Keywords
Transfusion, Intermittent hypoxia
Brief summary
The primary purpose of this observational study was to determine if pRBC transfusions decrease the frequency of intermittent hypoxia events in very low birth weight infants (VLBW) during the first six weeks of life. The impact on non-pRBC transfusions on the frequency of intermittent hypoxia was also assessed.
Interventions
OTHERTransfusion
pRBC and non-pRBC transfusions
Sponsors
Temple University Hospital
University of Pennsylvania
Pennsylvania Hospital
Christiana Care Health Services
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 6 Weeks
Inclusion criteria
* 23+0 to 28+6 weeks gestational age at birth
Exclusion criteria
* Infants with life-limiting diagnoses * Cyanotic heart disease * In utero fetal transfusion * Twin to twin transfusion syndrome * Isoimmune hemolytic disease * Severe acute hemorrhage * Acute shock * Sepsis with coagulopathy * Need for perioperative transfusion * Parents opposed to transfusion of blood * Parents with hemoglobinopathy or congenital anemia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in number of Intermittent hypoxia | Change in number of intermittent hypoxia before (approximately 8 hours) and after transfusion (approximately 8 hours). | An intermittent hypoxemia event is defined as a fall in oxygen saturations to less than 80% for \>/= 10 secs and \<3 minutes with a minimal time interval of 4 seconds between events. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hypoxia | 8 hours prior to transfusion and 8 hours after transfusion. | Percent time with oxygen saturations less than 85%, 80% and 75%. |
Countries
United States
Outcome results
None listed