Effect of Sedatives
Conditions
Brief summary
In the present study, we observe perioperative findings of electroencephalogram in sedated and non-sedated elderly patients undergoing total knee arthroplasty under spinal anesthesia.
Detailed description
In the present study, we observe perioperative findings of electroencephalogram in sedated and non-sedated elderly patients undergoing total knee arthroplasty under spinal anesthesia. Electroencephalogram is performed before, during, and 1 day after surgery. After the induction of anesthesia, sedation is performed according to the patient's request. If a patient want to be sedated during surgery, one of the three sedatives (dexmedetomidine, propofol, and midazolam) is administered.
Interventions
DEVICEElectroencephalogram
Electroencephalogram is performed before, during, and 1 day after surgery in elderly patients undergoing spinal anesthesia.
Sponsors
SMG-SNU Boramae Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Eldery patients scheduled for spinal anesthesia
Exclusion criteria
* MMSE ≤ 23 * Hemodynamic unstability * Liver disease * Renal disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| EEG frequency bands (alpha, beta, theta, delta, and gamma waves) during spinal anesthesia | 30 min after the induction of spinal anesthesia | EEG frequency bands are observed during spinal anesthesia under sedated or unsedated states. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| EEG frequency bands (alpha, beta, theta, delta, and gamma waves) 1 day after surgery | 1 day after surgery | EEG frequency bands are observed after surgery and compared with the preoperative findings. |
| Incidence of delirium | For 7 days after surgery. | Delirium is assessed after surgery. |
Outcome results
None listed