Laparoscopic Gastrectomy
Conditions
Brief summary
Investigators want to find the concentration of epidural ropivacaine, which can block hemodynamic changes in the onset of pneumoperitoneum in the laparoscopic gastrectomy.
Detailed description
According to previous patient's response, the investigators will allocate the concentration of ropivacaine of next patient during Co2 insufflation. And, for this allocation of concentration of ropivacaine, the investigators use biased coin design up-and-down method. Based on the practices, the starting concentration is 0.375 %, and the step size of concentration is 0.125%.
Interventions
DRUGRopivacaine
According to previous patient's response, the investigators will allocate the concentration of ropivacaine of next patient during Co2 insufflation. And, for this allocation of concentration of ropivacaine the investigators use biased coin design up-and-down method.
Sponsors
Keimyung University Dongsan Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing laparoscopic gastrectomy that require pneumoperitoneum * patients who has epidural catheter to manage postoperative pain control * patients who agree to our study
Exclusion criteria
* patients who don't agree to our study * BMI\<16.0 or BMI\>35 * cardiovascular disease, pulmonary disease, renal disease * alcoholic abuser or drug abuser * any use of local anesthetics or drugs which have an influence on cardiovascular system from beginning of induction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes from baseline in heart rate (bpm) after CO2 insufflation | immediately after CO2 insufflation : 1,2,3,4,5,6, 7, 8, 9, 10 minutes after CO2 insufflation | Heart rate will be recorded before anesthesia induction, during CO2 insufflation, after Co2 insufflation. The mean value of heart rate before anesthesia induction will be regarded as the baseline values. If maximum heart rate after Co2 insufflation increased by \>20% from baseline value, the response will be regarded as fail and increased concentration of ropivacaine will be applied to next patient by up and down method. |
| Changes from baseline in mean arterial pressure (mmHg) after CO2 | immediately after CO2 insufflation : 1,2,3,4,5,6, 7, 8, 9, 10 minutes after CO2 insufflation | Mean arterial pressure will be recorded before anesthesia induction, during CO2 insufflation, after Co2 insufflation. The mean value of mean arterial pressure before anesthesia induction will be regarded as the baseline values. If maximum mean arterial pressure after Co2 insufflation increased by \>20% from baseline value, the response will be regarded as fail and increased concentration of ropivacaine will be applied to next patient by up and down method. |
Contacts
Primary ContactJiwon Lee, Dr
Backup ContactHyung-wook Lim
Outcome results
None listed