Inhibitory Control: Effects of Modulation

Brain Circuitry of Inhibitory Control: Effects of Modulation

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04247334

Enrollment

117

Registered

2020-01-30

Start date

2019-11-14

Completion date

2024-02-25

Last updated

2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Young Adults

Brief summary

Inhibitory control is relevant to many clinical disorders, including substance abuse/dependence, obsessive-compulsive disorder, and attention-deficit hyperactivity disorder. This proposal is designed to assess brain networks related to response inhibition in healthy young adults, and use neuromodulation to change these networks and behavioral performance on a response inhibition task. Having an understanding of the brain mechanisms involved in response inhibition may enable us to improve pre-existing treatments for disorders with inhibitory control difficulties.

Interventions

DEVICETranscranial direct current stimulation

20 minutes of 2 milliamp transcranial direct current stimulation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 25 Years

Healthy volunteers

Yes

Inclusion criteria

1. Low (\<1sd below the mean on the BRIEF-Inhibit) or high (\>1sd above the mean on BRIEF-Inhibit scale) 2. English fluency to ensure comprehension of study measures and instructions.

Exclusion criteria

1. Presence of medical conditions contraindicated for tDCS, including history of any known intracranial pathology, epilepsy or seizures, traumatic brain injury, brain tumor, stroke, implanted medical devices, current pregnancy or women of childbearing age not using effective contraception, or any other serious medical conditions or health problems that would interfere with participation (e.g., skin condition) 2. Inability to undergo MRI 3. Current substance abuse disorder 4. Currently prescribed psychiatric medications. 5. Active mania or psychosis

Design outcomes

Primary

Measure	Time frame	Description
fMRI connectivity at rest	2 weeks	Changes in resting state connectivity of the inhibitory control information
fMRI connectivity during a stop signal task	2 weeks	Changes in task-based connectivity on the stop signal task

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 9, 2026