Bone Loss, Surgery
Conditions
Keywords
induced membrane, critical size defect
Brief summary
Bone reconstruction in critical sized defect (CSD) remains a real challenge in orthopedic surgery in children and adults. The Masquelet technique is an innovative therapeutic technique, which offers a bone reconstruction in two steps, by the formation of an induced membrane (IM) around a polymethylmethacrylate (PMMA) spacer placed into the bone defect. After, PMMA removal, the cavity is filled with corticocancellous graft allowing bone healing. Up to date, all angiogenesis and osteogenic properties of IM remain unknown. The purpose of this study is to characterize angiogenesis and osteogenic properties of IM in children and adults.
Interventions
PROCEDUREharvesting induced membrane
The induced membrane will be harvested during the second step of the bone reconstruction.
Sponsors
Centre Hospitalier Universitaire, Amiens
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
9 Months to 60 Years
Healthy volunteers
No
Inclusion criteria
* All patients treated at CHU Amiens-Picardie for bone critical sized defect treated using the induced membrane reconstruction technique. * patients from 9 months to 60 years old
Exclusion criteria
* Patients managed by another reconstruction technique for critical sized defect * Patients under guardianship, curators or deprived of liberty. * Pregnant and nursing women. * Patients who refused to participate in the study and to sign informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measure of the BMP2 concentration of the induced membrane by immunodetection | one year (one year from day of surgery) | Measure of the osteogenic property of the induced membrane will be made after harvesting the induced membrane |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| BMP2 concentration of the induced membrane implanted in adults measured by immunodetection | one year (one year from day of surgery) | measurement of osteogenic property of the induced membrane in adults |
| BMP2 concentration of the induced membrane implanted in children measured by immunodetection | one year (one year from day of surgery) | measurement of osteogenic property of the induced membrane in children |
Countries
France
Contacts
Primary ContactCéline Klein, MD
Outcome results
None listed