Brain Metastases
Conditions
Keywords
Laser Interstitial Thermal Therapy (LITT), Stereotactic radiosurgery (SRS), Magnetic resonance image (MRI)
Brief summary
The purpose of this study is to test whether an additional magnetic resonance image (MRI) sequence can improve the ability to distinguish radiation damage from tumor recurrence in participants with brain metastasis who have previously been treated with stereotactic radiosurgery (SRS).
Interventions
OTHERMRI
Subjects undergo one additional delayed MRI sequence
Sponsors
Duke University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients, age ≥18 * Metastatic malignancy with at least 1 brain metastasis previously treated with SRS * Patients may have also received whole brain radiation therapy (WBRT) for management of brain metastatic disease but this is not required for study participation * Patients must have been diagnosed with a metastatic solid tumor of any histological type except small cell lung cancer (SCLC), or lymphoma. * Radiographic progression on post-SRS imaging at previously treated SRS site(s) * Must be a candidate for brain surgery as determined by treating neurosurgeon and/or anesthesia team * Patients must sign study-specific informed consent prior to study entry
Exclusion criteria
* Poor surgical candidate as determined by treating neurosurgeon and/or anesthesia team * Unable to undergo contrasted MRI (e.g. incompatible medical device, inadequate renal function per standard institutional clinical protocol, contrast allergy) * Small cell lung cancer (SCLC) or lymphoma histology
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| number of positive MRI sequences along with positive tumor biopsies | baseline | true tumor will be detected by delayed MRI as determined by biopsy |
| number of negative MRI sequences along with negative tumor biopsies | baseline | absence of tumor will be detected by delayed MRI as determined by biopsy |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORScott Floyd, M.D. Ph.D.
Duke Health
Outcome results
None listed