Amyloidosis, Carpal Tunnel Syndrome
Conditions
Keywords
carpal tunnel syndrome, amyloidosis
Brief summary
Carpal tunnel syndrome has been suggested to be an early sign of amyloidosi. The investigators will evaluate tissue samples obtained from patients undergoing carpal tunnel release surgery for amyloid.
Detailed description
Carpal tunnel syndrome (CTS) can be caused by the deposition and accumulation of misfolded proteins called amyloid and is often an early manifestation of systemic amyloidosis. Patients with cardiac amyloidosis often have carpal tunnel syndrome that precedes cardiac manifestations by several years, and many patients will have undergone surgery for idiopathic carpal tunnel syndrome since the protein also deposits in the transversal carpal ligament of the hand. The investigators sought to identify the prevalence and type of amyloid deposits in patients undergoing carpal tunnel surgery and evaluate for cardiac involvement
Interventions
PROCEDURECarpal tunnel syndrome surgery
Biopsy
Sponsors
Corporacion Parc Tauli
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients undergoing carpal tunnel syndrome surgery
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with amyloid deposits in patients undergoing carpal tunnel surgery | 2 years | Prevalence of amyloid deposits in biopsy in patients undergoing carpal tunnel syndrome surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with cardiac involvement in echocardiogram | 2 years | Cardiac involment in echocardiography |
Countries
Spain
Contacts
Primary ContactMaria del Carmen Navarro-Saez, M.D.
Outcome results
None listed