Chronic Stable Angina Pectoris
Conditions
Keywords
meridians, acupuncture, chronic stable angina pectoris, meridian phenomena
Brief summary
This study is designed to detect the microcirculatory characteristics of meridian phenomena by using an objective assessment tool and investigate the site specificity for the meridian-visceral association and surface-surface association between two specific meridians.
Detailed description
The Lung and Heart meridians are chosen as two specific studied meridians. Participants of chronic stable angina pectoris (CSAP) and healthy volunteers will be enrolled. 120 participants will be included and divided into the healthy control group, chronic stable angina pectoris (CSAP) group and healthy intervention group. Laser doppler flowmetry (LDF) will be used to assess the microcirculatory characteristics of meridian phenomena for the Heart and Lung meridians. The site specificity for the meridian-visceral association will be investigated by comparing the microcirculatory difference between the Heart and Lung meridians in the healthy control group and CSAP group. Besides, participants in the healthy intervention group will receive two sessions of moxibustion in the Heart meridian and Lung meridian respectively to explore the site specificity for the surface-surface association.
Interventions
Two sessions of moxibustion will be performed in the Heart meridian and Lung meridian successively. Intervention in the Heart meridian: moxibustion will be performed above Shaohai (HT3) for 15 minutes. During moxibustion, the probes of laser doppler flowmetry will detect the microcirculatory characteristics of three measuring sites, which include the midpoint of the Heart meridian along the left forearm, Chize (LU5) of the Lung meridian, and the midpoint of the Lung meridian along the left forearm. Intervention in the Lung meridian: moxibustion will be performed above Chize (LU5) for 15 minutes. During moxibustion, the probes of laser doppler flowmetry will detect the microcirculatory characteristics of three measuring sites, which include the midpoint of the Lung meridian along the left forearm, Shaohai (HT3) of the Heart meridian, and the midpoint of the Heart meridian along the left forearm.
Laser doppler flowmetry will be used to detect the microcirculatory characteristics of meridian phenomena
Sponsors
Study design
Eligibility
Inclusion criteria
Inclusion criteria for the CSAP group * Patients should meet the diagnostic criteria of coronary heart disease, which includes the following items: 1)confirmed old myocardial infarction (MI), or a history of percutaneous coronary intervention(PCI), or coronary artery bypass grafting; 2)50% or more luminal stenosis in at least one coronary artery or major branch segment confirmed by coronary angiogram or CT angiography; 3) myocardial ischemia indicted by exercise stress radionuclide myocardial imaging; 4) treadmill exercise testing is positive (for male patients); * Patients should meet the diagnostic criteria of CSAP and the Canadian Cardiovascular Society(CCS) classification for CSAP is level II or III; * The medical history of CSAP is more than 3 months with attacks occurring at least twice weekly in the last month; * 35 ≤ age ≤75 years, male or female; * Patients have clear consciousness and could communicate with others normally; * Patients could understand the full study protocol and written informed consent is signed. Inclusion criteria for health volunteers * Healthy volunteers should provide a recent medical examination report to confirm they have not any cardiovascular, respiratory, digestive, urinary, hematological, endocrine and neurological disease; * age≥20 years, male or female; * Participants have clear consciousness and could communicate with others normally; * Participants could understand the full study protocol and written informed consent is provided by themselves or their lineal kin.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline blood flow curve | 5-minute baseline, 15 minutes during moxibustion and 5 minutes after stopping moxibustion | Laser doppler flowmetry is used to assess blood flow curve of relevant sites along the Heart and Lung meridians |
| Change from baseline blood perfusion units | 5-minute baseline, 15 minutes during moxibustion and 5 minutes after stopping moxibustion | Laser doppler flowmetry is used to assess blood perfusion units of relevant sites along the Heart and Lung meridians |
Countries
China