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The Microcirculatory Characteristics of the Heart and Lung Meridians: A Study of CSAP Patients and Healthy Adults

The Microcirculatory Characteristics of the Heart and Lung Meridians: A Study of CSAP Patients and Healthy Adults

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04244812
Enrollment
120
Registered
2020-01-28
Start date
2020-02-29
Completion date
2021-12-31
Last updated
2020-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Stable Angina Pectoris

Keywords

meridians, acupuncture, chronic stable angina pectoris, meridian phenomena

Brief summary

This study is designed to detect the microcirculatory characteristics of meridian phenomena by using an objective assessment tool and investigate the site specificity for the meridian-visceral association and surface-surface association between two specific meridians.

Detailed description

The Lung and Heart meridians are chosen as two specific studied meridians. Participants of chronic stable angina pectoris (CSAP) and healthy volunteers will be enrolled. 120 participants will be included and divided into the healthy control group, chronic stable angina pectoris (CSAP) group and healthy intervention group. Laser doppler flowmetry (LDF) will be used to assess the microcirculatory characteristics of meridian phenomena for the Heart and Lung meridians. The site specificity for the meridian-visceral association will be investigated by comparing the microcirculatory difference between the Heart and Lung meridians in the healthy control group and CSAP group. Besides, participants in the healthy intervention group will receive two sessions of moxibustion in the Heart meridian and Lung meridian respectively to explore the site specificity for the surface-surface association.

Interventions

OTHERMoxibustion

Two sessions of moxibustion will be performed in the Heart meridian and Lung meridian successively. Intervention in the Heart meridian: moxibustion will be performed above Shaohai (HT3) for 15 minutes. During moxibustion, the probes of laser doppler flowmetry will detect the microcirculatory characteristics of three measuring sites, which include the midpoint of the Heart meridian along the left forearm, Chize (LU5) of the Lung meridian, and the midpoint of the Lung meridian along the left forearm. Intervention in the Lung meridian: moxibustion will be performed above Chize (LU5) for 15 minutes. During moxibustion, the probes of laser doppler flowmetry will detect the microcirculatory characteristics of three measuring sites, which include the midpoint of the Lung meridian along the left forearm, Shaohai (HT3) of the Heart meridian, and the midpoint of the Heart meridian along the left forearm.

Laser doppler flowmetry will be used to detect the microcirculatory characteristics of meridian phenomena

Sponsors

The Third Affiliated hospital of Zhejiang Chinese Medical University
CollaboratorOTHER
The First Affiliated Hospital of Zhejiang Chinese Medical University
CollaboratorOTHER
Zhejiang Chinese Medical University
Lead SponsorOTHER_GOV

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
Yes

Inclusion criteria

Inclusion criteria for the CSAP group * Patients should meet the diagnostic criteria of coronary heart disease, which includes the following items: 1)confirmed old myocardial infarction (MI), or a history of percutaneous coronary intervention(PCI), or coronary artery bypass grafting; 2)50% or more luminal stenosis in at least one coronary artery or major branch segment confirmed by coronary angiogram or CT angiography; 3) myocardial ischemia indicted by exercise stress radionuclide myocardial imaging; 4) treadmill exercise testing is positive (for male patients); * Patients should meet the diagnostic criteria of CSAP and the Canadian Cardiovascular Society(CCS) classification for CSAP is level II or III; * The medical history of CSAP is more than 3 months with attacks occurring at least twice weekly in the last month; * 35 ≤ age ≤75 years, male or female; * Patients have clear consciousness and could communicate with others normally; * Patients could understand the full study protocol and written informed consent is signed. Inclusion criteria for health volunteers * Healthy volunteers should provide a recent medical examination report to confirm they have not any cardiovascular, respiratory, digestive, urinary, hematological, endocrine and neurological disease; * age≥20 years, male or female; * Participants have clear consciousness and could communicate with others normally; * Participants could understand the full study protocol and written informed consent is provided by themselves or their lineal kin.

Design outcomes

Primary

MeasureTime frameDescription
Change from baseline blood flow curve5-minute baseline, 15 minutes during moxibustion and 5 minutes after stopping moxibustionLaser doppler flowmetry is used to assess blood flow curve of relevant sites along the Heart and Lung meridians
Change from baseline blood perfusion units5-minute baseline, 15 minutes during moxibustion and 5 minutes after stopping moxibustionLaser doppler flowmetry is used to assess blood perfusion units of relevant sites along the Heart and Lung meridians

Countries

China

Contacts

Primary ContactYongliang Jiang, M.D
jyl2182@126.com86-13858173136
Backup ContactHantong Hu
413351308@qq.com86-18667103032

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 18, 2026