Hormonal Changes, Induction of Labor, Previous Cesarean Section
Conditions
Keywords
labor induction,, previous caesarean section, hormonal levels, breast stimulation, intracervical balloon
Brief summary
Objectives- To compare changes in labour-associated maternal and fetal hormone levels during breast stimulation, balloon induction and spontaneous labour. To compare efficacy and safety of labour induction methods in women with previous caesarean section. Design- Participants were randomized to undergo induction of labour by breast stimulation or intracervical balloon compared to spontaneous labour (controls). Setting- A single tertiary hospital Population- women at term, with previous caesarean section
Detailed description
Maternal serum levels of oxytocin, prostaglandin F2α, prostaglandin E2, prolactin, estradiol and cortisol levels were analyzed at 0, 3 and 6 hours post induction initiation, including the two groups catheter balloon and breast stimulation and controls in spontaneous labor. Fetal umbilical cord hormones were measured in the three mentioned above groups. Clinical outcomes were documented in the two induction groups.
Interventions
DEVICEinduction of labor by breast stimulation
DEVICEinduction of labor by catheter balloon
Sponsors
Western Galilee Hospital-Nahariya
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* uncomplicated pregnancy * 37-42 weeks of pregnancy * singleton pregnancy * cephalic presentation * previous one low transverse cesarean section * indicated induction of labour
Exclusion criteria
* fetal anomaly * past uterine rupture * previous preterm cesarean section * multiple pregnancy * polyhydramnios * any contraindication for vaginal delivery or catheter balloon insertion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes in labour-associated maternal and fetal hormone levels | at 0, 3 and 6 hours post induction initiation or at controls during the latent phase | Maternal serum levels of: oxytocin (pg/mL) were analyzed at 0, 3 and 6 hours post induction initiation (T1, T2, T3) - in two induction groups: catheter balloon and breast stimulation groups the above mentioned parameter was measured also in the third study group: women in their latent phase admitted to the delivery room - the parameter was measured at 0,3,6 hours post admission this parameter was also measured in fetal umbilical cord (F) in women of the three study groups each parameter presented above were reported separately for each group (median at T1, T2, T3 and F) and compared between the three groups inter and intra groups changes were examined |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To compare efficacy and safety of labour induction methods in women with previous caesarean section | at birth | the following clinical parameters were measured during the induction process or after delivery in the two induction groups (catheter balloon and breast stimulation): induction to delivery interval time in hours were measured after delivery in the two groups, medians were compared |
Countries
Israel
Outcome results
None listed