Hepatitis C
Conditions
Brief summary
Hepatitis C virus has been identified a quarter of a decade ago as a leading cause of chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma. Only a minority of patients can clear the virus spontaneously during acute infection. Elimination of HCV during acute infection correlates with a rapid induction of innate and a delayed induction of adaptive immune responses. The majority of patients is unable to clear the virus and develops viral persistence despite the ongoing innate and adaptive immune response. The virus usually develops several strategies to escape these immune responses.
Interventions
DIAGNOSTIC_TESTinterleukin IL-1beta and interleukin IL-18
pro-inflammatory cytokines measured in the serum
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
OTHER
Masking
NONE
Intervention model description
chronic hepatitis C virus patients
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Chronic hepatitis C virus patients. * Patients do not start treatment protocol.
Exclusion criteria
* Pregnant women. * Hepato-cellular carcinoma patients. * Autoimmune disease patients. * Patients with liver cirrhosis. * Patients who refuse to participate in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes in the exprssion level of inflammasomes | 6 monthes | observe the changes in the exprssion level of inflammasomes in the selected chronic HCV patients before treatment with Sofosbuvir 400 mg and Daclatasvir 60 mg daily for 12 weeks and after sustained virological response at 12 weeks following the end of treatment (SVR12). |
Contacts
Primary ContactKhaled Mohammed Hassanein, professor
Backup ContactHelal Foad Hetta, lecturer
Outcome results
None listed