Autism Spectrum Disorder
Conditions
Keywords
TMS
Brief summary
This study will evaluate the effects of repetitive Transcranial Magnetic Stimulation (rTMS) on neural and behavioral facets of social cognition in Autism Spectrum Disorder (ASD). Participant visits will include a baseline assessment of neuropsychological, cognitive and behavioral function, and an EEG (electroencephalogram) and eye-tracking session to measure neural and visual attentional social response before and after administration of TMS.
Detailed description
Broad ranging social cognition difficulties are hallmark areas of impairment in autism spectrum disorder (ASD), and they are subserved by specific neural systems underpinning social perception and processing that are recognized to be atypical in ASD. Considering the neurodevelopmental nature of the disorder, and the recent findings regarding aberrant neuroplasticity in ASD, repetitive transcranial magnetic stimulation (rTMS) holds promise to directly modulate brain activity in these systems. The objective of this research proposal is to utilize a multimodal approach to provide a proof-of-concept for the ability of rTMS to (a) influence functioning in the brain systems involved in social ASD symptomatology and (b) modify associated social cognitive behaviors in adults with ASD. Toward achieving this objective, we propose to assess critical aspects of social cognition using the electroencephalogram (EEG), event-related potentials (ERPS), eye-tracking (ET), and behavioral tasks prior to and following a single rTMS session to provide preliminary insight into the potential of rTMS as a tool to modify social brain function in cognitively able adults with ASD.
Interventions
BEHAVIORALTranscranial Magnetic Stimulation (TMS)
Subjects will receive both active and sham TMS in a randomized crossover assignment involving two study sessions
Sponsors
Yale University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* individuals between the ages of 18 and 40 years old with typical development or with a diagnosis of autism spectrum disorder. * able to participate in an EEG and eye-tracking experiment
Exclusion criteria
* Participants reporting significant head trauma or serious brain illness * Participants with major psychiatric illness that would preclude completion of study measures. * Participants with a history of serious medical illness, stroke, seizures, epileptiform EEG abnormalities, or family history of seizures. * Participants taking prescription medications that may affect cognitive processes under study. * Participants who have taken alcohol or recreational drugs within the preceding 24 hours. * Females of known/suspected pregnancy or who test positive on a pregnancy test. * Participants with a history of metalworking or injury by shrapnel or metallic objects are also exclude
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| right lateralized N170 latency to upright faces | Measures will be recorded for the duration of their visit, an expected average of 4-5 hrs. | EEG brain response to faces as measured by the N170 component in milliseconds |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| proportion of visual attention to the eye region of the face | Measures will be recorded for the duration of their visit, an expected average of 4-5 hrs. | visual attention to the eye region of the face as measured by eye tracking in seconds |
| The Benton Face Recognition Task | Measures will be recorded for the duration of their visit, an expected average of 4-5hrs | The total Benton score will be used to assess the ability to recognize and discriminate among faces |
Countries
United States
Outcome results
None listed