Single-lumen 5Fr and Triple-lumen 6Fr PICCs Are Accurate for Hemodynamic Measurement by Transpulmonary Thermodilution.

Single-lumen 5Fr and Triple-lumen 6Fr PICCs Are Accurate for Hemodynamic

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04241926

Enrollment

Registered

2020-01-27

Start date

2019-05-01

Completion date

2020-02-29

Last updated

2020-07-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Centrally Inserted Central Catheter, Hemodynamic Monitoring, Peripherally Inserted Central Catheters, Transpulmonary Thermodilution

Keywords

PICC, CICC, Cardiac output, shock

Brief summary

Peripherally inserted central catheters (PICCs) are increasingly used in intensive care unit (ICU) as an alternative to centrally inserted central catheters (CICCs) for intravenous infusion. In the present study the investigators try to assess their reliability for measuring cardiac index (CI) with trans-pulmonary thermodilution (TPTD) technique.

Interventions

DIAGNOSTIC_TESTtranspolmonary thermodilution

Thermodilution was attempted via PICC and via CICC in the same patient

Study design

Intervention model

CROSSOVER

Primary purpose

OTHER

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* adult patients (≥18 years) admitted to the ICU * Patients requiring hemodynamic monitoring using EV1000TM * Patients having both PICC and CICC in place (these patients had their PICC replaced with a CICC, usually at the time of ICU admission, or vice versa, usually at the end of their ICU stay, and were enrolled immediately after the placement of the new device before the previous one was removed)

Exclusion criteria

* body weight \<40 kg * severe aortic regurgitation or intra-cardiac shunt * treatment with an intra-aortic balloon pump * contraindication for placement of PICC, CICC or a femoral arterial catheter * abdominal aneurism * extracorporeal circulation * pregnancy * lack of informed consent

Design outcomes

Primary

Measure	Time frame	Description
Cardiac Index comparison via PICC	one hour	comparison of hemodynamic measurements made by the TPTD from the VolumeView/EV1000TM system via PICC vs. CICC.

Secondary

Measure	Time frame	Description
Comparison of single-lumen 5Fr PICCs to CICC	one hour	Comparison of single-lumen 5 Fr PICCs to CICC in their reliability of assessing cardiac output
Comparison of triple-lumen 6Fr PICCs to CICC	one hour	Comparison of triple-lumen 6 Fr PICCs to CICC in their reliability of assessing cardiac output

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 24, 2026