Renal Insufficiency, Spinal Cord Injuries
Conditions
Brief summary
Patients with long-term lower urinary tract dysfunction due to spinal cord injury presenting for a routine urodynamic control will be screened for inclusion and exclusion criteria. Suitable individuals providing written informed consent will undergo renal Doppler sonography and renal scintigraphy in addition to the routine examinations. Conclusions regarding renal function based on the clearance rate determined by scintigraphy (gold standard) will be compared with the conclusions based on Doppler sonography and Cystatin C clearance.
Interventions
DIAGNOSTIC_TESTrenal scintigraphy
Technetium-99m-dimercaptosuccinic acid scintigraphy of both kidneys
DIAGNOSTIC_TESTrenal doppler sonography
doppler ultrasound of both kidneys
Sponsors
Lotte und Adolf Hotz-Sprenger Stiftung
Swiss Paraplegic Research, Nottwil
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* long-term spinal cord injury (≥10 years) * age ≥30 years * written informed consent
Exclusion criteria
* dementia or severe intellectual impairment * serious internal illness * previous or current tumor disease * known allergy to the radioactive marker (Technetium) * pregnancy or breastfeeding * withdrawal of informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| renal clearance | at the time of inclusion into study | renal clearance of Technetium-99m-dimercaptosuccinic acid determined by scintigraphy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cystatin C concentration | at the time of inclusion into study | blood serum concentration of Cystatin C (mg/L) |
| Cystatin C clearance | at the time of inclusion into study | renal clearance of Cystatin C (ml/min) according to the Grubb formula |
| renal peak systolic velocity | at the time of inclusion into study | Doppler sonography evaluation of renal blood flow during systolic heart phase (m/s) |
| renal peak enddiastolic velocity | at the time of inclusion into study | Doppler sonography evaluation of renal blood flow during enddiastolic heart phase (m/s) |
| renal resistive index | at the time of inclusion into study | (systolic velocity - enddiastolic velocity) / systolic velocity |
Other
| Measure | Time frame | Description |
|---|---|---|
| size of kidneys | at the time of inclusion into study | size of kidneys evaluated by sonography |
| age | at the time of inclusion into study | time from birth to inclusion into study (years) |
| renal tissue echogenicity | at the time of inclusion into study | renal tissue echogenicity evaluated by sonography |
| bladder evacuation method | at the time of inclusion into study | method of bladder evacuation |
| lesion level | 1 year after spinal cord injury | highest intact spinal cord segment |
| lesion severity | 1 year after spinal cord injury | severity of spinal cord injury according to American Spinal Injury Association Impairment Score (AIS) (A = motor and sensory complete, B = motor complete and sensory incomplete, C & D = motor and sensory incomplete, E = motor and sensory intact) |
| duration of spinal cord injury | at the time of inclusion into study | time from spinal cord injury to inclusion into study (years) |
Countries
Switzerland
Outcome results
None listed