Pain, Postoperative
Conditions
Brief summary
Video-assisted thoracoscopic (VATs) lobectomy is mild to moderately pain procedure. For conventional thoracotomy, there are many invasive pain control such as epidural analgesia, paravertebral block. However, for VATs, the invasive pain control somehow are too invasive. Nefopam is non-opioid painkilling medication, Serotonin, norepinephrine, dopamine reuptake inhibitor. Many study were demonstrated positive outcome of nefopam usage in many operation such as abdominal surgery, laparocopic surgery, orthopedic surgery. Nevertheless, nefopam for VATs is not well studied yet.
Interventions
DRUGNefopam 20 MG/ML
Nefopam group nefopam 20 mg during surgery and follow by 80 mg in 24 hours postoperative
DRUGPlacebo
Placebo
Sponsors
Mahidol University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Schedule to video-assisted thoracoscopic surgery : VATs lobectomy * Can operate a patient-controlled analgesia (PCA) device * No contraindication for nefopam
Exclusion criteria
* Epilepsy, on monoamine oxidase (MAO) inhibitors, glaucoma * Creatinine clearance \< 60 ml/min * Liver disease: child-pugh score B or C * Allergy to nefopam * Chronic opioid use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| morphine consumption in first 24 hours post-operative | 24 hours | morphine consumption record from patient-controlled analgesia machine in 24 hours post-operative |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| numeric pain score | 24 hours | numeric pain score in 1, 2, 12, 24 hours after surgery |
| side effect of nefopam | 24 hours | side effect of nefopam: tachycardia, sweating, nausea, vomiting, sedation |
Countries
Thailand
Outcome results
None listed