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Perioperative Recommendations for Medication Safety

Global PRoMiSe (Perioperative Recommendations for Medication Safety): A Consensus-Based, Generalizable Approach

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04240301
Enrollment
120
Registered
2020-01-27
Start date
2023-08-16
Completion date
2027-12-31
Last updated
2026-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative Medication Safety

Keywords

medication safety, anesthesiology, perioperative

Brief summary

The purpose of the proposed research is to create and disseminate expert-based recommendations for perioperative medication safety that are tailored to country income level, using the World Bank's four country income groups: high, upper-middle, lower-middle, and low income. The specific aims of the research are to: 1) Develop consensus-based perioperative medication safety recommendations, 2) Prioritize the recommendations by their level of clinical importance for implementation in high, upper-middle, lower-middle and low income countries, and disseminate the recommendations; and 3) Evaluate the initial adoption of the recommendations in each country income group.

Detailed description

The overall objective of the proposed research is to create and disseminate expert-based recommendations for perioperative medication safety that are tailored to country income level, using the World Bank's four country income groups: high, upper-middle, lower-middle, and low income. The proposed project will include the entire medication use process (ordering, dispensing, preparing, administering, documenting and monitoring). The specific aims of the research are to: 1. Develop consensus-based perioperative medication safety recommendations. Approach: This study will use the extensively studied RAND-UCLA Delphi Method to achieve consensus, with an expert panel consisting of anesthesiologists, surgeons, nurses and medication safety experts from each of the World Bank's four country income groups. 2. Prioritize the recommendations by their level of clinical importance for implementation in high, upper-middle, lower-middle and low income countries, and disseminate the recommendations. Approach: The expert panel members will rank each recommendation by its importance as a next step in improving medication safety in each country income group. A Condorcet ranking method will be used to combine individual rankings into a single list of recommendations ranked by the importance of implementation for each country income group. The investigators will then execute a comprehensive dissemination strategy. 3. Evaluate the initial adoption of the recommendations in each country income group. Approach: The investigators will conduct qualitative, one-on-one, semi-structured interviews of the expert panel members, to evaluate their perceptions of initial adoption of the recommendations in each country income group. A grounded theory approach will be used to identify common themes.

Interventions

None listed

Sponsors

Karen C. Nanji,M.D.,M.P.H.
Lead SponsorOTHER
World Federation of Societies of Anesthesiologists
CollaboratorUNKNOWN
University of California, San Francisco
CollaboratorOTHER
Aga Khan University
CollaboratorOTHER
University of Toronto
CollaboratorOTHER
University of Minnesota
CollaboratorOTHER
University of Auckland, New Zealand
CollaboratorOTHER

Study design

Observational model
OTHER
Time perspective
OTHER

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Anesthesiologists, surgeons, operating room nurses, nurse anesthetists, pharmacists and patient safety experts

Exclusion criteria

* None

Design outcomes

Primary

MeasureTime frameDescription
Expert-based medication safety recommendations.3 yearsFour tiers of stepwise recommendations, corresponding to each of the World Bank's four country income groups.

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORKaren C. Nanji, M.D., M.P.H.

Massachusetts General Hospital

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 9, 2026