Anesthesia, Colo-rectal Cancer
Conditions
Keywords
Postoperative pain, Opioid consumption, Intraoperative anesthesia
Brief summary
The investigators designed a multi-center prospective randomized controlled trial to study the influence of the type of anesthesia on postoperative pain after laparoscopic colorectal cancer surgery. Half of the participants will be anesthetized with propofol and remifentanil, while the other half will be anesthetized with sevoflurane and remifentanil during the surgery. The investigators will measure opioid consumption and pain score in the acute postoperative phase.
Detailed description
Previous studies showed that patients receiving total intravenous anesthesia (TIVA) with propofol are associated with less postoperative pain and less opioid consumption compared with inhalation anesthesia. However, some studies showed conflicting results. In colorectal surgery, there are only retrospective studies that showed the analgesic effect of TIVA and inhalation anesthesia. The investigators designed a multi-center prospective randomized controlled trial and hypothesized that TIVA with propofol would be associated with reduced postoperative opioid consumption and less postoperative pain compared with sevoflurane in laparoscopic colorectal cancer surgery.
Interventions
DRUGPropofol
General anesthesia during the laparoscopic colorectal surgery is achieved by using a target-controlled intravenous infusion of propofol.
DRUGSevoflurane
General anesthesia during the laparoscopic colorectal surgery is achieved by using an inhalation agent (Sevoflurane).
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Adult patient scheduled for elective laparoscopic colorectal cancer surgery
Exclusion criteria
* Pregnant * Conversion from laparoscopic to open surgery * Allergy to anesthetics and analgesics * Previous abdominal surgery * Chronic pain * Chronic analgesic usage
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative 24 h opioid consumption | 24 hours after the surgery | Cumulative opioid consumption for pain control 24 hours after the surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative 48 h opioid consumption | 48 hours after the surgery | Cumulative opioid consumption for pain control 48 hours after the surgery |
| Numerical rating scale (NRS) | 24 and 48 hours after the surgery | Numerical rating scale (NRS) pain score 24 and 48 hours after the surgery. NRS is an 11-point scale for patient self-reporting of pain; 0-10 where 0 is no pain and 10 is the worst pain imaginable. |
Countries
South Korea
Outcome results
None listed