Sarcopenia
Conditions
Brief summary
Sarcopenia is the loss of muscle mass and function with age. It has been recognised as an important health problem because it is common in older adults and associated with decline in physical function as well as a reduced quality of life. Sarcopenia can also lead to serious health consequences in terms of increased disability and the need for increased health and social care. There is considerable interest in understanding what causes sarcopenia in order to develop new approaches to prevention, diagnosis and treatment. To gain a detailed understanding of sarcopenia across a range of ages, we have designed the Muscle Ageing Sarcopenia Study (MASS\_Lifecourse) in collaboration with members of the public and patients.
Detailed description
We aim to recruit 160 participants from Newcastle upon Tyne across an age range of 45-85 years from primary care, secondary care and the NIHR (National Institute for Health Research) Bioresource. Participants will receive a home visit from a researcher to complete a detailed health profile. Participants will then be invited to attend a clinical visit at Newcastle's Campus for Ageing and Vitality for imaging and muscle biopsy. A subsequent clinical visit will involve a fasting blood test, follow-up of the biopsy site and gather participants' views about taking part in the study. The aims of the study: 1. To determine if it is acceptable and feasible to recruit adults across a range of ages to undergo detailed studies of skeletal muscle including biopsy 2. To understand how lifestyle is related to the characteristics of muscle 3. To use advances in technology (an omics approach) to identify mechanisms of sarcopenia and biomarkers for early diagnosis 4. To use findings from 2 and 3 to develop new approaches to treatment and also to invite participants to relevant trials 5. To secure funding for maintaining and expanding the cohort
Interventions
OTHERObservational study: range of clinical and lifestyle factors
Medical conditions and medications. Educational and occupational history. Lifestyle exposures, assessed using reduced Food Frequency Questionnaire, Rapid Assessment of Physical Activity questionnaire and objectively-measured physical activity levels over 7 days using a GeneActiv wrist-worn accelerometer (Activinsights, Cambridge, UK).
Sponsors
Newcastle-upon-Tyne Hospitals NHS Trust
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
45 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
Primary care source: \- Registered patient with one of the GP (General Practice) surgeries identified as PIC (Participant Identification Centre) via North East and North Cumbria Clinical Research Network. Secondary care source: \- Attending a NuTH (Newcastle upon Tyne Hospitals NHS Foundation Trust) clinical area. NIHR Bioresource: \- Participants identified by the NIHR Bioresource Centre Newcastle as being eligible for the study and who have not previously expressed a wish to no longer be contacted about further studies. For all recruitment sources: * Has capacity to consent. * Within the study age range (45-85 years). * Not taking any anticoagulant or antiplatelet medications (see below under
Exclusion criteria
), with the exception of aspirin being taken for primary prevention (i.e. where there is no diagnosis of cardiovascular disease).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sarcopenia phenotype- walking speed | Baseline | Usual walking speed (m/s) |
| Sarcopenia phenotype- grip strength | Baseline | Maximum grip strength (Kg) |
| Sarcopenia phenotype- chair rise time | Baseline | Time to complete 5 chair rises (seconds) |
| Sarcopenia phenotype- appendicular lean mass | Baseline | Appendicular lean mass from DXA Scan (Kg) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Presence of Frailty | Baseline | Fried frailty Score |
| Cognitive and Psychosocial Function | Baseline | Montreal Cognitive Assessment (MoCA) Score |
| Geriatric Depression Scale | Baseline | Geriatric Depression Scale Score |
| Patient-reported survey of patient health | Baseline | Short Form 36 (SF-36) |
Countries
United Kingdom
Contacts
Primary ContactRichard M Dodds, MBBS PhD
Outcome results
None listed