Premature Birth
Conditions
Keywords
Lung function, Exercise
Brief summary
This study will explore lung function and respiratory health in school-aged children who were born prematurely at \<32 weeks gestation. It will involve full lung function assessment, a questionnaire and discussion about respiratory health, and an exercise test using optoelectronic plethysmography (OEP) to measure breathing patterns.
Detailed description
Preterm are born during a critical stage of lung development, and can have abnormalities in lung function that persist with age. Previous studies have shown that children with BPD have reduced lung function and limited exercise capacity. These studies have used conventional lung function testing which requires a tight fitting mask. This is uncomfortable, may alter normal breathing patterns and cannot measure changes in total lung volume. Optoelectronic plethysmography (OEP) indirectly measures lung volumes and breathing patterns using cameras to track the position of marker stickers on the chest, back and abdomen. It is comfortable, does not require a mask and allows us to track changes in total lung volume. This study will use standard lung function testing and OEP to measure lung function and breathing patterns at rest and during exercise in school-aged children born prematurely, compared to healthy children born at full term. All participants will complete standard lung function tests, a questionnaire and structured interview to qualitatively assess respiratory health, and an exercise test using OEP to assess how breathing changes with exercise.
Interventions
DIAGNOSTIC_TESTLung function + exercise tests
Lung function + exercise tests
Sponsors
Northumbria University
Newcastle-upon-Tyne Hospitals NHS Trust
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
8 Years to 16 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 8-16 years * Born at \<32 weeks gestation (preterm) or \>37 weeks gestation (controls) * Parental consent obtained
Exclusion criteria
* Unable to comply with test procedure * Respiratory illness within last 2 weeks * Cardiac disease (excludes ligated PDA) * Neuromuscular disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in end-expiratory lung volume with exercise | Pre + post exercise (10minutes) | Change in end-expiratory lung volume measured in litres with exercise measured using optoelectronic plethysmography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in minute ventilation with exercise | During exercise (10 minutes) | Change in minute ventilation (measured in litres/minute) with exercise measured using optoelectronic plethysmography. |
| Baseline forced expiratory volume in 1 second (FEV1) | Baseline | Baseline forced expiratory volume (in litres) in 1 second measured by spirometry (FEV1) |
| Forced vital capacity (FVC) | Baseline | Baseline forced vital capacity measured in litres (FVC) |
| Forced mid-expiratory flow (FEF25-75%) | Baseline | Mean forced expiratory flow between 25% and 75% of FVC measured in litres/second (FEF25-75%) |
| Change in tidal volume with exercise | During exercise (10 minutes) | Change in tidal volume with exercise measured in litres using optoelectronic plethysmography |
| Body plethysmography | Baseline | Baseline lung volume (in litres) measured using body plethysmography |
| FeNO | Baseline | Baseline FeNO (fraction of exhaled nitric oxide) |
| Exercise induced bronchoconstriction | 10 minutes post exercise | % change in FEV1 |
| Baseline activity levels | 1 week period | Baseline activity levels measured using Actigraph monitor |
| Transfer factor for carbon monoxide (TLCO) | Baseline | Transfer factor for carbon monoxide (measured in millimoles per minute per kilopascal) using single breath test |
Countries
United Kingdom
Contacts
Primary ContactRebecca J Naples, BMBCh
Outcome results
None listed