Skin Condition
Conditions
Brief summary
To assess Chenopodium Formosanum and Fagopyrum Esculentum Extract on skin anti-aging
Interventions
DIETARY_SUPPLEMENTPlacebo drink
consume 2 bottle (30 mL) per day for 56 days
DIETARY_SUPPLEMENTChenopodium Formosanum and Fagopyrum Esculentum Extract drink
consume 2 bottle (30 mL) per day for 56 days
Sponsors
TCI Co., Ltd.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy adults aged between 20-65 years old * Subjects must read and sign the informed consent form after the study has been fully explained. * Subjects are willing to cooperate and comply with all of the regulation during the trial. * Subject should inform to investigator immediately if adverse effect is happened. * Subjects are willing to avoid UV overexposure during the trial (include indoor tanning treatment).
Exclusion criteria
* Subjects who have known cosmetic, drug or food allergies. * Subjects who have severe desquamation, tattoo, sunburn, peeling skin or other skin condition might impact measurement. * Subjects with any physical condition judged by the researcher not to be eligible for this study. * Subjects with uncontrollable physical condition such as high blood pressure, thyroid disease, diabetes, etc. * Female who is pregnant or nursing or planning to become pregnant during the course of the study. * Those who are currently participating in other clinical trials or who have just concluded a clinical trial two weeks ago. * Women who have started contraceptive or change current hormone contraceptive methods within 3 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The change of skin L*a*b* value | Change from Baseline skin L*a*b* value at 8 weeks | Color Spectrophotometer SCM-104/108 is utilized to measure skin L\*a\*b\* value. Units: arbitrary units |
| The change of skin elasticity | Change from Baseline skin elasticity at 8 weeks | Cutometer® dual MPA 580 is utilized to measure skin elasticity (parameter R2). Units: μm penetration depth into the probe opening, expressed as curves |
| The change of skin wrinkles | Change from Baseline skin wrinkles at 8 weeks | 3D Full-Face Skin Analyzer IRV is utilized to measure wrinkles. Units: arbitrary units |
| The change of skin collagen density | Change from Baseline skin collagen density at 8 weeks | DermaLab® combo - 20 MHz High Freq. Ultrasound probe is utilized to scan and analyze skin collagen density. Units: Intensity score |
| The change of skin tone | Change from Baseline skin tone at 8 weeks | 3D Full-Face Skin Analyzer IRV was utilized to measure skin tone. Units: arbitrary units |
| The change of skin brightness | Change from Baseline skin brightness at 8 weeks | 3D Full-Face Skin Analyzer IRV is utilized to measure skin brightness. Units: arbitrary units |
| The change of skin melanin index | Change from Baseline skin melanin index at 8 weeks | Mexameter® MX 18 is utilized to measure skin melanin index. Units: arbitrary Mexameter® units (0-999) |
| The change of skin moisture | Change from Baseline skin moisture at 8 weeks | Corneometer® CM825 is utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The change of skin texture | Change from Baseline skin texture at 8 weeks | 3D Full-Face Skin Analyzer IRV is utilized to measure skin texture. Units: arbitrary units |
| The change of skin pores | Change from Baseline skin pores at 8 weeks | 3D Full-Face Skin Analyzer IRV is utilized to measure skin pores. Units: arbitrary units |
| The change of skin spots | Change from Baseline skin spots at 8 weeks | 3D Full-Face Skin Analyzer IRV is utilized to measure skin spots. Units: arbitrary units |
| The change of skin erythema level | Change from Baseline skin erythema level at 8 weeks | Mexameter® MX 18 is utilized to measure skin erythema level. Units: arbitrary Mexameter® units (0-999) |
| Self-assessment questionnaire | 8 weeks | Questionnaire is utilized to assess skin condition of the subjects. Units: score |
| The change of transepidermal water loss (TEWL) | Change from Baseline TEWL at 8 weeks | Tewameter® TM 300 is utilized to measure transepidermal water loss. Units: g/hm² |
Countries
Taiwan
Outcome results
None listed