Psychosis
Conditions
Keywords
source-monitoring, at-risk, MRI, neuroimaging
Brief summary
Source-monitoring is a cognitive process that refers to the ability to remember the source of an information. Some studies have showed source-monitoring deficits in patients with schizophrenia as well as in individuals at ultra-high risk for psychosis (UHR) and in first-episode psychosis patients (FEP). Source-monitoring deficits have thus been proposed as a potential early risk factor for psychosis. However, further studies are needed to better characterize this deficit. The aim of this project is to investigate source-monitoring performances in UHR, FEP patients and healthy controls (HC) and to characterize these deficits in terms of brain anatomy, basic auditory processes and social functioning.
Detailed description
Ninety participants will be included in the study: 30 UHR, 30 FEP and 30 healthy controls. All the participants will complete a standardized source-monitoring task, an MRI acquisition (3D-T1 anatomical scan), a tone-matching task as well as a socio-demographic and clinical evaluation including an assessment of the social functioning.
Interventions
OTHERCognitive tests and neuroimaging
comparison of cognitive performances and brain anatomy
Sponsors
Hôpital le Vinatier
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Three groups of participants will be recruited: individuals at ultra-high risk for psychosis, first-episode psychosis patients and healthy controls.
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Men and Women aged between 18 and 30 * Having given their written informed consent * French speakers and readers * Absence of hearing impairments (or tinnitus) that could prevent the successful completion of tasks involving listening to sounds or words * Absence of visual impairments that could prevent the successful completion of tasks involving reading on the screen * For the healthy control group, no history of previous diagnosed psychiatric disorders (according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders - DSM5), absence of relatives diagnosed with spectrum disorder schizophrenia and bipolar disorder (DSM5), absence of psychotic prodromes measured by a score of less than 6 in the prodromal questionnaire - PQ-16 (Ising et al., 2012), absence of drug treatments (except oral contraception). * For the UHR group, meeting the UHR criteria according to the Comprehensive Assessment of at-risk mental state (CAARMS). * For the FEP group, presenting with daily psychotic symptoms for at least a week.
Exclusion criteria
* Do not consent to be included in the study * Contraindication to MRI scan * History of neurological disease * Pregnancy * Being under tutorship or curatorship * Having developed musical abilities (that is, regularly practicing a musical instrument)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Source-monitoring performances | one day | Scores obtained at a source-monitoring task (Brunelin et al., 2006) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Grey matter volume | one day | Grey matter volume will be assessed with a structural MRI scan (3D-T1) followed by morphometry analyses. |
| Brain gyrification | one day | Brain gyrification will be assessed with a structural MRI scan (3D-T1) followed by gyrification analyses. |
| Confidence in source-monitoring judgements | one day | Confidence in source-monitoring judgements will be measured using a visual analogue scale (0-100) |
| Working memory performances | one day | scores at a working memory task (Barrouillet et al., 2004) |
| Social functioning | one day | score at the personal and social performance scale (0-100) |
| Basic auditory performances | one day | scores at the Tone Matching Task (Strous et al., 1995) |
Countries
France
Contacts
Primary ContactLydie sartelet
Outcome results
None listed