Erosion, Localized, Shoulder Injury Related to Vaccine Administration
Conditions
Brief summary
Accidental vaccine injection into adjunct shoulder structures can cause tissue damage, termed Shoulder injury related to vaccine administration (SIRVA). The immunopathological mechanisms and consequences of SIRVA are unknown. The study assesses the clinical and immunological consequences of an influenza vaccine if accidentally administered in periarticular space.
Interventions
DIAGNOSTIC_TESTUltrasound Shoulder and Immunological Phenotyping by FACS
Cross-sectional Ultrasound exam of the affected shoulder. Peripheral blood measurements of the T and B cell subsets. Anti-Influenza Antibody measurements
Sponsors
University Hospital, Basel, Switzerland
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* participation at a local vaccination campaign * Shoulder pain \>3 days after vaccination
Exclusion criteria
* no vaccine received * preexisting shoulder pathology
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pathological Findings in Ultrasound | Ultrasound of the shoulder is performed at Baseline/Inclusion | Cross-sectional assessment and description of pathological ultrasound findings in subjects with shoulder pain after influenza vaccination |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Increased Vaccine response | Baseline and 12 months | Antibodies against Influenza, Plasmablasts and T follicular helper cell increase |
Countries
Switzerland
Outcome results
None listed