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Comparison of Articaine and Prilocaine for Extraction of Maxillary Teeth

Does Articaine, Rather Than Prilocaine, Increase the Success Rate of Anaesthesia for Extraction of Maxillary Teeth

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04236115
Enrollment
95
Registered
2020-01-22
Start date
2017-09-20
Completion date
2018-06-20
Last updated
2020-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overcoming the Failure of Anaesthesia, Maxillary Teeth, Dental Extraction

Keywords

Carticaine, dental extraction, injections, prilocaine

Brief summary

Ninety-five patients, aged between 16 and 70 years old, were included in this study. Patients were divided into two groups. Group one received Articaine 4% with 1:00.000 Adrenalines. Group two received Prilocaine with 3% Felypressin (0.03 I.U. per ml). Onset time of anaesthesia was objectively evaluated by using electronic pulp testing.

Detailed description

85 patients in this study had successful local anaesthetic followed by extraction within the study duration time (10 minutes). However, there were six patients with failure anaesthesia (5 in prilocaine group and 1 in articaine group). By application Person's Chi-square test (x2), there were no significant differences in the number of the episodes of the anaesthetic success between articaine and prilocaine groups at time intervals (P-value = 0.5). T- test showed there have been no important variations within the mean onset time of anaesthesia for articaine and prilocaine buccal infiltrations (P-value =0.1).

Interventions

Articaine 4% is dental local anaesthetic agent

DRUGPrilocain 3%

prilocaine is dental local anaesthetic agent

adrenaline is a vasoconstrictor

DRUGFelypressin

Felypressin is a vasoconstrictor

Sponsors

Taibah University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Intervention model description

double blinded randomised trial

Eligibility

Sex/Gender
ALL
Age
16 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

* Patients have one or two upper teeth for extraction, subject tooth or its adjacent must be vital, healthy patient or patient with mild systemic diseases (class I or II according to American Society of Anesthesiology).

Exclusion criteria

* Patients excluded from this study if they have allergy to local anaesthetic agents or need surgical, or multiple teeth extraction.

Design outcomes

Primary

MeasureTime frameDescription
Does articaine, rather than prilocaine, increase the success rate of anaesthesia for extraction of maxillary teeth6 monthsto compare the anaesthetic performances of 3% prilocaine (the safest local anaesthetic) with 4 % articaine (the local anaesthetic with fastest onset time of action) when used for maxillary teeth extraction

Countries

Saudi Arabia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 18, 2026