Anticholinergic Toxicity, Fall, Frailty
Conditions
Brief summary
We hypothesized that the use of anticholinergic medications may precipitate falls differently by frailty status in older adults. Community-dwelling older subjects admitted to the Geriatrics Outpatient Clinic prospectively enter into the study. Frailty status is defined according to the Physical Frailty Phenotype. The drugs are categorized according to the ACB scale
Detailed description
Previous studies have found that the use of drugs with anticholinergic properties relate to increased prevalence of falls in older women and men. Frailty is associated with serious health outcomes including falls, hip fractures, and death. Frailty can be a relevant target to investigate its association with the risk of falls among the users of drugs with anticholinergic properties. A recent evidence suggests that the interaction between being frail and adverse outcomes in older adults receiving polypharmacy or centrally acting drugs is complex and not straightforward across all frailty phenotypes. We classify the participants frail if they met at least three of five criteria, while those having one or two criteria were pre-frail, and others were non-frail. We determine the anticholinergic burden by using the Anticholinergic Cognitive Burden (ACB) Scale developed by Boustani et al.
Interventions
DIAGNOSTIC_TESTFall assessment
Through a comprehensive geriatric assessment carried out by our geriatrician led multidisciplinary team we gather information about fall recalls consistent with the definition of landing on the floor or ground.
Sponsors
Saglik Bilimleri Universitesi
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Community-dwelling older adults
Exclusion criteria
* a history of dementia, * current delirium or psychotic symptoms, * taking antipsychotic medications, * being functionally dependent to others, * difficulty in communicating with the interviewer, * terminal illness, * being bedridden or wheelchair bound (≥2 weeks), * difficulty in standing or walking, * incomplete data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fall assessment | 1-2 hours | We will assess the association between anticholinergic burden (ACB) and falls based on frailty status among older adults. |
Countries
Turkey (Türkiye)
Contacts
Primary ContactMehmet I Naharci, Assoc.Prof.
Outcome results
None listed