Invasive Pulmonary Aspergillosis and Severe Influenza

Is Invasive Pulmonary Aspergillosis a Common Complication of Severe Influenza ?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04232956

Acronym

ASPERGIGRIPP

Enrollment

478

Registered

2020-01-18

Start date

2018-07-27

Completion date

2018-11-05

Last updated

2020-01-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aspergillosis, Critical Illness, Influenza

Brief summary

Invasive pulmonary aspergillosis (IPA) has been reported in critically ill patients with influenza infection with a highly variable incidence between 1 to 21%. Studies investigating IPA in critically ill patients with influenza infection suffer limitations in their methods. It remains unknown whether patients with influenza are more at risk of IPA than other patients hospitalized in intensive care unit and whether patients with influenza who develop IPA have specific risk factors for this infection. Our study aims to determine the incidence of IPA in a large multicenter cohort and to identify risk factors for IPA in these patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Infection with influenza A or B * Admission to one of the participating sites

Exclusion criteria

* age \< 18 * patients with invasive pulmonary aspergillosis prior to intensive care admission * consent withdraw

Design outcomes

Primary

Measure	Time frame	Description
Invasive Pulmonary Aspergillosis	up to 100 days	incidence of invasive pulmonary aspergillosis

Countries

France

Outcome results