Chronic Inflammation, NASH - Nonalcoholic Steatohepatitis, Obesity, Morbid
Conditions
Keywords
obesity, nash, adipose tissue inflammation, insulin resistance
Brief summary
This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin resistance.
Interventions
PROCEDUREBariatric surgery
Evaluate liver fibrosis by elastography before gastric bypass surgery.
Sponsors
Mayo Clinic
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Undergoing gastric bypass surgery * Confirmed AUROC F=0 or F\>2 liver fibrosis * Age 30-70 years * BMI greater than 40 kg/m2 * Negative pregnancy test (female only) * Lab Values: Normal TSH
Exclusion criteria
* Autoimmune diseases * Hepatitis B or C positive * Heavy alcohol use * Active smoking history * Active cancer history * History of asthma * History of COPD * Taking Plavix or Coumadin * Blood donation within past 2 months * Glucocorticoid Therapy * Taking antihistamine on regular basis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Liver fibrosis | Baseline | evaluate the liver fibrosis by elastography before surgical intervention |
| Adipose tissue inflammation | Baseline | Evaluate markers of adipose tissue inflammation by mRNA levels |
Countries
United States
Contacts
CONTACTKeegan M Stewart
PRINCIPAL_INVESTIGATORElena Anna O De Filippis
Mayo Clinic
Outcome results
None listed