Bronchoscopy
Conditions
Keywords
Computer simulation, Multislice computed tomography
Brief summary
Advances in medical imaging technology have made it possible to detect patients with small-sized lung lesions early. Generally, invasive methods such as PCNA were used to diagnose peripheral lung nodule. However, Radial probe endobronchial ultrasonography (RP-EBUS) is widely used in the histological diagnosis of peripheral lung nodule in recent years. In order to carry out RP-EBUS, it is necessary to know the path to the lesion to access it. Conventionally, the path to the peripheral lung nodule is identified by the drawing, but recently, the path is reviewed by the virtual bronchoscopy navigation (VBN) which is reconstructed 3-dimension image using the CT data. Currently, VBN is driven by using raw data acquired using standard thin sectioned chest CT protocol, but the problem is that additional doses of radiation are exposed to patients who have initially discovered lung lesions using low dose CT. Therefore, we conduct a randomized controlled trial to verify the suitability of VBN using the raw data acquired by low dose CT.
Detailed description
The standard thin sectioned protocol CT consists of scout, enhanced and non-enhanced image. Therefore, in this study, non-enhanced protocol CT was taken with low dose protocols with three different radiation doses to acquire raw data and drive VBN, and compared with the VBN result driven with raw data obtained with standard protocol. The primary endpoint of this study is to verify the consistency and accuracy of the VBN results driven by the raw data obtained with the low dose protocol CT.
Interventions
DIAGNOSTIC_TESTChest CT
Low dose CT taken with three different protocols
Sponsors
Pusan National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Inclusion Criteria: 1. Patients older than 18 years 2. Competent to give informed consent 3. Patients requiring a pathological diagnosis of pulmonary nodules using RP-EBUS. 4. Patients who need chest CT before RP-EBUS. 2.
Exclusion criteria
1. Pregnancy 2. Patients who could not receive chest CT 3. Inability to obtain informed consent 4. Patients unable to perform RP-EBUS
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concordance rate of VBN simulation results | From CT scan to VBN drive (an average of 1 week) | Concordance rate comparing the VBN result driven based on raw data acquired with low dose CTs taken with three different protocols compared to the VBN result driven based on raw data obtained with standard protocol CT. |
Countries
South Korea
Outcome results
None listed