Hydrocephalus in Infants
Conditions
Brief summary
Investigation of the cerebrospinal fluid proteom in preterm infants with posthemorrhagic hydrocephalus in our neonatology center with analysis for modulation of proteom in dependence of breastmilk feeding and way of application such as via gavage tube, oral or nasal application.
Detailed description
Since the nasal route might be highly effective for neurotrophins and other growth factors the cerebrospinal fluid will be investigated using mass spectrometry to identify modulating effects of intranasal breast milk application on the cerebrospinal fluid proteom.
Interventions
OTHERno intervention
no intervention, only observational.
Sponsors
University Hospital of Cologne
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Days to 12 Months
Healthy volunteers
No
Inclusion criteria
* preterm infant with hydrocephalus and regular drainage
Exclusion criteria
* Inborn error of metabolism
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cerebrospinal fluid proteom | weeks | Cerebrospinal fluid analysis using mass spectrometry including proteomic analysis for differences in dependence of intranasal breast milk application |
Countries
Germany
Contacts
Primary ContactTitus Keller, MD
Backup ContactAngela Kribs, MD
Outcome results
None listed