Alcohol; Harmful Use, Glucose Intolerance, Metabolic Disturbance
Conditions
Brief summary
Examination of the effect of one week's unhealthy lifestyle on glucose metabolism and liver parameters in a group of young, healthy males participating in Roskilde Festival 2016.
Detailed description
Metabolic effects of intermittent unhealthy lifestyle in otherwise young healthy adults are poorly studied. The investigators evaluated the effect of one week's unhealthy lifestyle on glucose metabolism and liver parameters in a group of young, healthy males participating in Roskilde Festival 2016. Festival participants were studied before and after participation (one week) in Roskilde Festival 2016 and matched with controls who lead a normal life for an equivalent period of time. An oral glucose tolerance test (OGTT), abdominal ultrasound and strain elastography for liver stiffness were performed together with a bioimpedance scan and cognitive tests.
Interventions
BEHAVIORALFestival participation
One week's participation in Roskilde Festival 2016 or living a normal daily life.
Sponsors
University Hospital, Gentofte, Copenhagen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI of 18,5-25 kg/m2 * Normal liver function (assessed by ASAT, ALAT, GGT, alkaline phosphatase, albumin and bilirubin, coagulation factors II, VII and X, INR and platelets)
Exclusion criteria
* Planning alcohol withdrawal or dieting/a special low-fat diet during Roskilde Festival * Diabetes or pre-diabetes * First degree relatives with diabetes * Kidney disease (eGFT\<60 ml/min and/or albuminuria) * Chronic diseases (in addition to those already mentioned) that could affect participation in festival activities (concerts and parties) * Any condition in which the investigator believed would make it impossible to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Impairment of glucose tolerance | First day after intervention week | Evaluated by OGTT |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hepatic steatosis | First day after intervention week | Evaluated by abdominal ultrasound scan |
Other
| Measure | Time frame | Description |
|---|---|---|
| Altered cognitive function | First day after intervention week | Evaluated by validated cognitive test (SCIP) |
Outcome results
None listed