Microbial Colonization
Conditions
Brief summary
To identify differences in the intestinal microbiota by metagenomics analyses between lean and obese subjects
Interventions
OTHERobservational
Sponsors
Oy Medfiles Ltd
4Pharma Ltd.
Danisco
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
1. Females. 2. Age between 20 to 50 years. 3. Obtained his/her informed consent after verbal and written information. 4. Sufficient general health and orientation for participating in the study as evaluated by the study personnel. 5. Have a high probability for compliance with and completion of the study. 6. Available for study visits and availability for food 7. Normal gastrointestinal function. 8. Willingness to provide faecal, urine and blood samples and keep food diary
Exclusion criteria
Lactobacillus Rhamnosus GG or reuteri, bifidobacteria enriched products) in the past 6 weeks. 12. Use of anti-obesity drugs. 13. Active or recent (last 3 months) participation in a weight loss program including weight change (increase or loss) of 3 kg during the past three months. 14. Special diets e.g. Vegetarian, Vegan, Diets with intention to use certain limited food groups only (like paleo diet, egg-grape diet etc.) 15. History of chronic active inflammatory disorders. 16. History of bariatric surgery. 17. Regular use of non-steroidal anti-inflammatory drugs, corticosteroids, or equivalent immunomodulatory drugs. 18. Ongoing or recent (last 3 months) antibiotic treatment. 19. Immunosuppression or ongoing therapy causing immunosuppression. 20. Use of vitamin supplementations beyond Recommended Daily Intake levels during the previous 2 months and during the study, except for vitamin D supplementation up to 20 μg/day.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| evaluate the differences in the intestinal microbiota profile between lean and obese subjects. | 1 week |
Outcome results
None listed