Acid-Base Balance, Metabolism and Minerals

Acid-Base Balance Disorder, Metabolic Acidosis

acid-base balance, energy metabolism, protein-rich diet, alkaline supplementation, calorimetry, microdialysis, randomized placebo-controlled trial

Metabolism is controlled by macro- and micronutrients. Protein-rich diets should lead to latent acidosis at tissue level with further negative implications. Food supplements with alkaline salts are available and popular pretending to prevent these changes. Within a randomized double-blind placebo-controlled trial, the investigators tested the hypotheses 1) that a 4-week protein-rich diet induces a latent tissue acidosis and 2) an alkaline supplement can compensate this. Acid-base balance and important metabolic parameters were determined before and after 4 weeks of supplementation by peripheral blood samples, indirect calorimetry and muscle microdialysis before and after a protein-rich test meal.

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