Two- Dimensional Speckle Tracking Echocardiography After Primary Percutaneous Coronary Intervention

The Role of Two- Dimensional Speckle Tracking Echocardiography in Prediction of Remodeling and Major Adverse Cardiovascular Events in ST Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04228510

Enrollment

204

Registered

2020-01-14

Start date

2020-03-31

Completion date

2021-12-31

Last updated

2020-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Infarction

Brief summary

ST-segment elevation myocardial infarction (STEMI) is a major cause of morbidity and mortality worldwide. In spite of decrease in acute and long-term mortality following STEMI in parallel with more use of reperfusion therapy, such as primary percutaneous coronary intervention (PPCI), modern antithrombotic therapy, and secondary prevention, mortality remains considerable. Reduced EF is a well-known predictor of increased short and long term major adverse cardiovascular events MACE :( heart failure, stroke and death)

Interventions

PROCEDURE2D speckle tracking echocardiography

Global and segmental strain and strain rate in longitudinal and circumferential directions will be detected after PPCI; before discharge. The LV circumferential strains and strain rates will be determined from the short-axis views at the basal, middle, and apical levels, and longitudinal strains and strain rates will be determined from the apical 2-, 3-, and 4-chamber views of the LV. Segmental longitudinal strains equal to -15% or closer to 0 will be considered abnormal (injured segments). The average segmental longitudinal strain and strain rate of the abnormal segments is defined as the injury longitudinal strain (InjLS) and injury longitudinal systolic strain rate (InjLSRs).

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* ST elevation myocardial infarction patients after primary percutaneous coronary intervention

Exclusion criteria

* Previous myocardial infarction. * Sever or haemodynamically significant (associated with chamber dilation) valvular heart diseases. * Previous heart failure. * Previous cerebrovascular strokes. * Atrial fibrillation. * Severe comorbidities as severe renal impairment, hepatic or respiratory failure. * Bad equality views which affects accurate speckle tracking imaging.

Design outcomes

Primary

Measure	Time frame	Description
The Incidence of major adverse cardiovascular events	1 year	the rate of Acute coronary syndrome, Heart failure, Stroke and all-cause mortality

Contacts

Primary ContactAly Tohamy, MD

Ali.tohamy@gmail.com01006258877

Backup ContactAyman Khairy, MD

Aymankhairy11@gmail.com01094438055

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026