Comparative Study for Treatment of Alopecia Areata Using Carboxytherapy and Intralesional Steroids

Does Carboxytherapy Play a Role in Alopecia Areata Either Solely or in Combination? Comparative Study for Treatment of Alopecia Areata Using Carboxytherapy and Intralesional Steroids

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04228029

Enrollment

Registered

2020-01-14

Start date

2019-08-20

Completion date

2020-04-20

Last updated

2020-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alopecia Areata

Brief summary

Patients with three lesions of alopecia areata are randomly recruited in this study. Each lesion is randomized in to receiving either carboxytherapy in one lesion, intralesional steroids in another lesion and combination of both in the third lesion. Treatment period is 3 months followed by a follow-up period of 2 months.

Interventions

DEVICECarboxytherapy

Carbon dioxide (CO2) gas in injection form

DRUGIntralesional Steroid Injection

triamcinolone acetonide 8 mg/mL

Study design

Allocation

RANDOMIZED

Intervention model

SEQUENTIAL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* early localized scalp alopecia areata * patients who did not receive any medication for at least 2 months before starting the study Patients who agreed to join the study and signed written consent.

Exclusion criteria

* pregnant, and lactating females and those with unrealistic expectation. * Alopecia totalis or universalis or ophiasis or cicatrising alopecia * Usage of systemic treatment of alopecia areata 2 months prior to the study. * Any scalp lesion within the treated area * Bleeding diathesis, severe anemia or platelet disorders * Medical conditions such as autoimmune diseases.

Design outcomes

Primary

Measure	Time frame	Description
Severity of Alopecia Tool (SALT) score	6months-1 year	evaluate efficacy of carboxytherapy versus intralesional steroids versus combination of both Minimum value is 0% and maximum value is100% the higher the score the more the hair loss
Dermoscopy	6months-1 year	evaluate efficacy of carboxytherapy versus intralesional steroids versus combination of both through counting number dystrophic hair, tapered hair, regrowing hair, black dots, and yellow dots
blinded observer evaluation by use of photography	6months-1 year	evaluate efficacy of carboxytherapy versus intralesional steroids versus combination of both
patient satisfaction rate	6months-1 year	evaluate efficacy of carboxytherapy versus intralesional steroids versus combination of both

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 23, 2026