Attention Impaired, Cerebrovascular Disorders, Neglect, Hemispatial, Spatial Neglect, Stroke
Conditions
Keywords
Neglect, Recovery of function, Rehabilitation, Videogame, Post-stroke
Brief summary
The aim of this study is to investigate the effect of training with an adaptive computer game, in comparison to standard training, in the rehabilitation of stroke survivors suffering from spatial neglect.
Detailed description
Many stroke survivors who have suffered right brain damage show spatial neglect (SN), a deficit of spatial attention orienting that causes unawareness for stimuli located in the left hemispace. Recent data show that the execution of concurrent tasks (that is, multitasking) can worsen the clinical condition and impact functional recovery. The aim of this study is to investigate the effect of an adaptive computer game Labyrinth previously validated on health population. The videogame is designed for training both attention and execution functions as it engages spatial navigation and multitasking. The effect of the computer game will be compared to standard computerized exercises used for neglect rehabilitation. The investigators plan to administer to a sample of 30 stroke patients with SN both Labyrinth and standard trainings for 10 sessions each. The two trainings will be delivered in a randomized crossover design. Improvements of patients' performance will be registered across trainings and in a follow-up test at 1 month, by assessing the severity of SN and functional everyday outcomes. The investigators expect that patients' performance will improve following both types of training, but with stronger improvement for the adaptive videogame.
Interventions
DEVICEAdaptive computer game training
Patients sit in front of a computer monitor and play the adaptive videogame with a joystick. The game requires to orient and move inside a maze, and it includes phases that engage multitasking abilities. The level and speed of the game is adapted online to patients' performance.
DEVICEStandard computerized training
Patients sit in front of the computer monitor and perform simple computerized exercises using a keyboard to respond. Exercises are organized into modules according to the trained cognitive functions. Patients will perform four different modules that are designed for neglect rehabilitation. The level of exercises adapts periodically based on patient's performance.
Sponsors
IRCCS San Camillo, Venezia, Italy
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Masking description
Patients will be informed to take part in an experimental study on the rehabilitation of attention delivered through a computer game. Specific information about the rationale of the study will not be conveyed to patients. Both trainings will be administered, with the aim to support patients' autonomy in performance.
Intervention model description
Both experimental and control trainings will be administered consecutively to all patients. Each type of training will be delivered for 10 sessions, with order of training randomized across participants.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* First stroke patients with right brain damage * Right-handed * Preserved Italian language comprehension to provide informed consensus * Clinical signs of spatial neglect (diagnosis by BIT)
Exclusion criteria
* Prior history of psychiatric or neurological disease * Substance abuse * Inability to sustain the experimental trainings
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes at Behavioral Inattention Test (BIT) | Baseline; immediately after the first training; immediately after the second training; finally after 3 weeks from the end of second training | Diagnostic test for spatial neglect, composed by different subtests of spatial attention |
| Changes at KF-NAP scale | Baseline; immediately after the first training; immediately after the second training; finally after 3 weeks from the end of second training | Test for everyday functional outcome |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes at Load Test | Baseline; immediately after the first training; immediately after the second training; finally after 3 weeks from the end of second training | Computerized test on spatial monitoring and multitasking abilities |
| Changes at Apple Test | Baseline; immediately after the first training; immediately after the second training; finally after 3 weeks from the end of second training | Test for allocentric and egocentric spatial neglect |
Countries
Italy
Contacts
Primary ContactFrancesca Meneghello, M.D.
Outcome results
None listed