Anastomosis, Perfusion
Conditions
Keywords
tissue perfusion, hyperspectral imaging, fluorescence imaging, idocyaningreen (ICG)
Brief summary
In this study, gastrointestinal anastomoses are examined with a hyperspectral camera and after this the investigators use the Standard Routine ICG-Imaging. At the end, both methods will be compared..
Detailed description
All gastrointestinal anastomoses were examined in all patients with written informed consent. As Standard in our clinical Routine the tissue perfusion is measured with fluorescence Imaging and Indocyaningreen (ICG). In this study the investigators use the Hyperspectral-Camera (HSI-Camera) as new method. The measurements were performed like described before, using the TIVITA Tissue system (Diaspective Vision GmbH, Am Salzhaff, Germany). This HSI-camera provides hyperspectral images with a high spectral resolution (5 nm) in the visible and near infrared range (500-1000 nm). A RGB image and 4 false color images that represent physiologic parameters are intraoperatively provided by an analysis software. This work is focused on tissue oxygenation (StO2), which represents the relative blood oxygenation in the microcirculation of superficial tissue layers (approximately 1 mm) and the near-infrared (NIR) Perfusion Index, representing tissue layers in 4-6 mm penetration depth. As Standard method ICG-Fluorescence Imaging is used. After the procedure the Perfusion data of both Systems is compared.
Interventions
DIAGNOSTIC_TESTHyperspectral-Imaging
Photos were taken with the hyperspectral camera of the gastrointestinal anastomosis.
DIAGNOSTIC_TESTIndocyaningreen-Fluorescence imaging
Photos were taken with the Fluorescence camera after injection of the indocyaningreen-dye of the gastrointestinal anastomosis
Sponsors
University of Leipzig
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* all gastrointestinal anastomoses
Exclusion criteria
* inability to consent * allergy against indocyaningreen dye
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Tissue oxygenation (StO2) in % | After the intraoperative Photo is taken, within 5 minutes | Directly after the photo has been taken, the distribution of the spectra and their intensity is evaluated with the help of computer assisted analysis software. The software calculates the tissue oxygen saturation value (StO2) in percent. These values are measured at a standardized distance from the anastomosis region. |
| Anastomotic Perfusion in arbitrary units | After the intraoperative Photo is taken, within 5 minutes | Directly after the photo has been taken, the distribution of the spectra and their intensity is evaluated with the help of computer assisted analysis software. The software calculates the tissue perfusion in arbitrary units. (Method is described in attached literature) These values are measured at a standardized distance from the anastomosis region. |
Countries
Germany
Contacts
Primary ContactBoris Jansen-Winkeln, MD, PD
Backup ContactInes Gockel, MD, Prof.
Outcome results
None listed