Volatile Organic Compounds (VOCs) of Exhaled Breath in Patients With GI Bleeding

Analysis of Volatile Organic Compound (VOC) in Exhaled Breath for the Detection of Gastrointestinal Bleeding

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04226079

Enrollment

Registered

2020-01-13

Start date

2020-01-31

Completion date

2020-07-31

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal Hemorrhage, Volatile Organic Compounds

Brief summary

Cross sectional case-control study investigating the difference of volatile organic compound in the exhaled breath of the patients with GI bleeding and normal population.

Detailed description

This study investigates the difference of volatile organic compound in the exhaled breath of the patients with GI bleeding and normal population. We aimed to find out the biomarkers for GI bleeding.

Interventions

DIAGNOSTIC_TESTCollection of exhaled breath

Collection of exhaled breath will be analyzed for specific volatile organic compounds which show different distribution between groups

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Adults aged between 20 and 80 * Low possibility of gastrointestinal bleeding was proven by esophagogastroduodenoscopy and colonoscopy which were performed within 1 year. * NSAID non-user (within 1 months before the date of inclusion)

Exclusion criteria

* Diagnosis of malignancy diagnosed within 5 years * Past medical history of chronic liver disease, chronic kidney disease, chronic lung disease, chronic bronchial disease, asthma * Surgical history of any kind of gastrectomy * Surgical history of any kind of lung resection which could impact the patient's lung function.

Design outcomes

Primary

Measure	Time frame	Description
VOC Patterns	1 day of 1st emergency room (ER) visit for GI bleeding	Patterns of volatile organic compounds recognized by sensor array

Secondary

Measure	Time frame	Description
Measurement of VOC	1 day of 1st emergency room (ER) visit for GI bleeding	Qualitative and quantitative assay of volatile organic compounds by GC-MS
Change of VOC patterns	2nd visit (about 2weeks apart from 1st visit)	Change of the patterns of volatile organic compounds recognized by sensor array after recovery from GI bleeding

Countries

South Korea

Contacts

Primary ContactJIN JU CHOI, M.D.

wallet87@hanmail.net01028087284

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026