Thymectomy
Conditions
Keywords
Video-assisted thoracoscopic surgery, Subxiphoid approach
Brief summary
Surgerys used in thymectomy for myasthenia gravis and anterior mediastinal tumours have become much less invasive in recent years. In our study, the surgical technique which resected the thymus below the xiphoid process and the technique which was regarded as conventional video- assisted thoracoscopic surgery (VATS) thymectomy was compared.
Interventions
PROCEDURESubxiphoid surgery procedure
Subxiphoid procedure for thymectomy
PROCEDUREVATS surgery procedure
VATS procedure for thymectomy
Sponsors
The Second Hospital of Shandong University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Thymoma with or without myasthenia gravis； 2. Generalized myasthenia gravis not sensitive to conservative medicine treatment; 3. Good cardiopulmonary function.
Exclusion criteria
1. Cardiopulmonary function can't bear surgery; 2. Generalized myasthenia gravis with MuSK(+).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Duration of hospital stay | with 7 days | in days |
| Operation time | one day | in minutes |
| The amount of blood loss | one day | in milliliter |
| Duration of drainage | with 7 days | in days |
| Visual Analogue Scale of postoperative pain | within 3 days | in score |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Recurrence rate | 5 years | Recurrence rate after 5 year follow-up of thymectomy for thymoma |
| Overall survival | within 10 years | Overall survival in rate |
| Complete remission rates | 5 years | Complete remission rates after 5 year follow-up of thymectomy for myasthenia gravis |
Countries
China
Contacts
Primary ContactYunpeng Zhao
Outcome results
None listed