MEK Inhibitor-Associated Serous Retinopathy
Conditions
Keywords
MEK Inhibitor-Associated Serous Retinopathy, Hair dye, Aromatic amines
Brief summary
Hair dye products could induce minimal forms of MEKAR retinopathies (Mitogen-activated Extracellular signal-regulated Kinase - inhibitors associated retinopathies). These minimal forms of MEKAR are likely to be underdiagnosed, since the associated visual loss is usually mild and so this condition should be considered when patients report blurred vision. The aim of the study is to analyze whether in the current population that dyes the hair, minimal forms that go unnoticed by MEKAR retinopathies can be induced.
Interventions
DEVICEOCT-B scan
OCT-B scan (Optical coherence tomography)
Sponsors
Fondation Ophtalmologique Adolphe de Rothschild
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Hair dye up to one month before the inclusion * Hair dye product containing aromatic amines
Exclusion criteria
* Pregnant or lactating woman * Retinal pathology already known, or central serous choroiditis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| % of patients with MEKAR retinopathy detected on OCT-B scan | Day of inclusion, up to one month month after the last hair dye | Physiological parameter : Serous retinal detachment at the posterior pole, detected on OCT-B scan |
Countries
France
Outcome results
None listed