Erector Spinae Plane Block Versus Perioperative Intravenous Lidocaine for Thoracotomy

Erector Spinae Plane Block Versus Perioperative Intravenous Lidocaine for Postoperative Pain Control in Patients Undergoing Thoracotomy: A Prospective, Randomized, Double-blind Controlled Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04221880

Enrollment

Registered

2020-01-09

Start date

2021-09-29

Completion date

2022-03-15

Last updated

2022-05-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thoracic Diseases

Brief summary

Thoracotomy surgery is the most painful of all surgical procedures. Inadequate postoperative pain control in these patients may cause serious morbidity related to pulmonary, cardiovascular and emotional systems. Erector Spinae Plane Block (ESPB) was first described in 2016 and, it is frequently used for postoperative analgesia in thoracic surgery. Intravenous lidocaine exhibit analgesic activity through both the peripheral and central nervous system. Intravenous lidocaine has been shown to reduce postoperative pain intensity and accelerate postoperative recovery in many surgeries. The investigators aimed to compare the effect of lidocaine infusion and erector spinae plane block on postoperative opioid consumption and pain scores.

Interventions

DRUGBupivacaine Hcl 0.25% Inj

Ultrasound-guided erector spinae plane block with 20 ml %0.25 bupivacaine

DRUGSaline Solution for Block

Ultrasound-guided erector spinae plane block with 20 ml saline

DRUGSaline Solution intravenously

Same volume saline solution bolus and infusion as Group Lidocaine

DRUGLidocaine

1.5 mg / kg lidocaine iv. bolus and, 1.5mg / kg / h lidocaine iv. infusion

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* American Society of Anesthesiologist's physiologic state I-III patients undergoing thoracotomy surgery

Exclusion criteria

* chronic pain, bleeding disorders, renal or hepatic insufficiency, non cooperative patient, * Patients with allergies to one of the drugs used in the study.

Design outcomes

Primary

Measure	Time frame	Description
Opioid Consumption	First 24 hours total opioid consumption	First 24 hours total fentanyl consumption with patient controlled analgesia

Secondary

Measure	Time frame	Description
Visual analog pain score	Postoperative 24 hour	Post operative pain will be evaluated with a Visual Analogue Scale (VAS) score of 0-10 (0= no pain and 10= worst imaginable pain) at first hour postoperatively.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026