Gynecologic Disease, Inflammation
Conditions
Keywords
inflammation mediators, lymphocyte activation, natural orifice endoscopic surgery, neutrophil activation, platelet activation, vaginal hysterectomy
Brief summary
The authors aimed to detect inflammatory marker changes in two natural orifice hysterectomies: single-port laparoscopic hysterectomy (SLH) and vaginal hysterectomy (VH). Between 2018 and 2019, data obtained from patients in the SLH and VH groups were reviewed retrospectively. The preoperative and postoperative hematocrit (HCT), hemoglobin (HB), white blood cell (WBC), platelet (PLR), and neutrophil-lymphocyte (NLR) ratios and values were compared as well as the demographic characteristics of the patients.
Interventions
DEVICESingle port laparoscopic systems
The first assistant handles the scope from the patient's right side. The second assistant, who is positioned between the legs of the patient, inserts a uterine manipulator (Rumi System; Cooper Surgical, CT). At the beginning of the surgery, a 1.5 to 2.5 cm vertical incision is made within the umbilicus using the open Hasson approach. After the bottom retractor ring of the wound retractor component of the Octo-Port is inverted (DalimSurgNet, Seoul, Korea), it is inserted through the incision deep in the peritoneum. Carbon dioxide is insufflated through the gas valve of the Octo-Port to maintain intra-abdominal pressure at 10 to 12 mm Hg. Through the 10 mm channels of the Octo-Port, a 10 mm, 30° rigid laparoscope is introduced. Rigid laparoscopic instruments are introduced through the 5 mm channels of the Octo-Port. The utero-ovarian ligament or infundibulopelvic ligament, uterine vessels, and uterine ligaments are transected by using the 5 mm LigaSure vessel sealer device
Sponsors
Derince Training and Research Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
45 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* hysterectomy requirement with any conditions in gynecologic diseases
Exclusion criteria
* patients with a chronic disease (e.g., hypertension, diabetes mellitus, and rheumatologic, nephrological, and hematological diseases) * the presence of active infection * using of corticosteroid, acetylsalicylic acid, or anticoagulant * cystocele or rectocele repair with mesh
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in hemoglobin levels | 1 day | Hemoglobin levels in the first 24 hours after single port laparoscopic or vaginal hysterectomies were compared. |
| Changes in white blood cell levels | 1 day | white blood cell (x103/mm3), in the first 24 hours after single port laparoscopic or vaginal hysterectomies were compared. |
| Changes in hematocrit levels | 1 day | Hematocrit (%) levels in the first 24 hours after single port laparoscopic or vaginal hysterectomies were compared. |
| Changes in neutrophil-lymphocyte and platelet-lymphocyte ratio | 1 day | neutrophil-lymphocyte and platelet-lymphocyte ratio in the first 24 hours after single port laparoscopic or vaginal hysterectomies were compared. |
Countries
Turkey (Türkiye)
Outcome results
None listed